| Accession | ARO:3002676 |
| Synonym(s) | catB4 |
| CARD Short Name | catB3 |
| Definition | catB3 is a plasmid or chromosome-encoded variant of the cat gene found in Salmonella typhimurium, Acinetobacter baumannii and Escherichia coli. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+p+wgs, Acinetobacter pittiip+wgs, Acinetobacter townerig, Aeromonas caviaeg+p+wgs+gi, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+wgs, Alcaligenes faecalisg+wgs+gi, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Comamonas testosteronip+wgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesp+wgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatap, Lysobacter oculig+gi, Morganella morganiig+p+wgs+gi, Proteus mirabilisg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescensp+wgs, Shigella flexnerip+wgs, Shigella sonneiwgs, Vibrio choleraep+wgs |
| Resistomes with Sequence Variants | Achromobacter xylosoxidansg+wgs, Acinetobacter baumanniig+p+wgs, Acinetobacter johnsoniiwgs, Acinetobacter pittiip+wgs, Acinetobacter townerig, Acinetobacter wuhouensisp, Aeromonas caviaeg+p+wgs+gi, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisg+wgs+gi, Burkholderia cenocepaciawgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Comamonas testosteronip+wgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs+gi, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesp+wgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatap, Lysobacter oculig+gi, Morganella morganiig+p+wgs+gi, Proteus mirabilisg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs, Pseudomonas putidag, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescensp+wgs, Shigella flexnerip+wgs, Shigella sonneiwgs, Vibrio choleraep+wgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Wang M, et al. 2003. Antimicrob Agents Chemother 47(7): 2242-2248. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. (PMID 12821475) Tosini F, et al. 1998. Antimicrob Agents Chemother 42(12): 3053-3058. Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium. (PMID 9835490) Bunny KL, et al. 1995. Antimicrob Agents Chemother 39(3): 686-693. New mobile gene cassettes containing an aminoglycoside resistance gene, aacA7, and a chloramphenicol resistance gene, catB3, in an integron in pBWH301. (PMID 7793874) Houang ET, et al. 2003. Antimicrob Agents Chemother 47(4): 1382-1390. Epidemiology of rifampin ADP-ribosyltransferase (arr-2) and metallo-beta-lactamase (blaIMP-4) gene cassettes in class 1 integrons in Acinetobacter strains isolated from blood cultures in 1997 to 2000. (PMID 12654674) |
Prevalence of catB3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 82.61% | 0% | 47.33% | 0% |
| Acinetobacter baumannii | 0.18% | 0.05% | 0.45% | 0% |
| Acinetobacter johnsonii | 0% | 0% | 1.82% | 0% |
| Acinetobacter pittii | 0% | 0.49% | 0.28% | 0% |
| Acinetobacter towneri | 12.5% | 0% | 0% | 0% |
| Acinetobacter wuhouensis | 0% | 4.55% | 0% | 0% |
| Aeromonas caviae | 18.18% | 7.79% | 13.98% | 33.33% |
| Aeromonas hydrophila | 3.08% | 3.9% | 2.42% | 0% |
| Aeromonas veronii | 5.45% | 1.54% | 2.81% | 0% |
| Alcaligenes faecalis | 10% | 0% | 2.94% | 33.33% |
| Burkholderia cenocepacia | 0% | 0% | 0.22% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 5.45% | 0% |
| Citrobacter freundii | 1.64% | 8.62% | 9.48% | 0% |
| Citrobacter koseri | 0% | 15% | 4.5% | 0% |
| Citrobacter portucalensis | 0% | 14.71% | 14.41% | 0% |
| Citrobacter werkmanii | 0% | 0% | 5.13% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Comamonas testosteroni | 0% | 50% | 7.14% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 1.98% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter cloacae | 0% | 1.68% | 4.15% | 0% |
| Enterobacter hormaechei | 0.72% | 1.35% | 4.62% | 6.67% |
| Enterobacter kobei | 0% | 2.07% | 0.87% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 1.08% | 0% |
| Escherichia coli | 0.31% | 0.35% | 1.27% | 1.28% |
| Escherichia fergusonii | 0% | 0.71% | 1.09% | 0% |
| Klebsiella aerogenes | 0% | 4.35% | 0.85% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 50% |
| Klebsiella michiganensis | 0% | 9.14% | 4.79% | 0% |
| Klebsiella oxytoca | 2.56% | 3.42% | 1.68% | 0% |
| Klebsiella pneumoniae | 0.36% | 0.98% | 1.63% | 5.71% |
| Klebsiella quasipneumoniae | 0% | 0.85% | 2.37% | 0% |
| Leclercia adecarboxylata | 0% | 4.76% | 0% | 0% |
| Lysobacter oculi | 100% | 0% | 0% | 50% |
| Morganella morganii | 21.15% | 12.5% | 9.2% | 15.38% |
| Proteus mirabilis | 27.52% | 6.25% | 5.28% | 22.22% |
| Proteus penneri | 0% | 0% | 25% | 0% |
| Providencia alcalifaciens | 9.09% | 0% | 0% | 0% |
| Providencia rettgeri | 2.94% | 0% | 1.27% | 0% |
| Providencia stuartii | 0% | 0% | 9.09% | 0% |
| Pseudomonas aeruginosa | 0% | 2.63% | 0.73% | 0% |
| Pseudomonas putida | 1.41% | 0% | 0% | 0% |
| Raoultella planticola | 0% | 6.98% | 12.82% | 0% |
| Salmonella enterica | 0.95% | 3.12% | 0.77% | 2.65% |
| Serratia marcescens | 0% | 0.65% | 0.26% | 0% |
| Shigella flexneri | 0% | 1.2% | 0.31% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 350