| Accession | ARO:3002681 |
| CARD Short Name | catB9 |
| Definition | catB9 is a chromosome-encoded variant of the cat gene found in Vibrio cholerae. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Vibrio choleraeg+wgs+gi |
| Resistomes with Sequence Variants | Vibrio choleraeg+wgs+gi |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance + antibiotic inactivation enzyme |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Heidelberg JF, et al. 2000. Nature 406(6795): 477-483. DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. (PMID 10952301) Rowe-Magnus DA, et al. 2002. Mol Microbiol 43(6): 1657-1669. Bacterial resistance evolution by recruitment of super-integron gene cassettes. (PMID 11952913) |
Prevalence of catB9 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Vibrio cholerae | 27.35% | 0% | 46.33% | 66.67% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400