| Accession | ARO:3002683 |
| Synonym(s) | cat1 catI |
| CARD Short Name | catA1 |
| Definition | catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+wgs+gi, Aeromonas caviaeg+wgs, Aeromonas hydrophilag+p, Alcaligenes faecaliswgs, Burkholderia malleiwgs, Citrobacter freundiig+p+wgs, Citrobacter koseriwgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniiwgs, Comamonas testosteroniwgs, Cronobacter sakazakiiwgs, Cupriavidus metalliduranswgs, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Enterococcus faecaliswgs, Escherichia albertiig, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Helicobacter pylorig, Klebsiella aerogeneswgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Leclercia adecarboxylatawgs, Morganella morganiig+wgs, Neisseria gonorrhoeaewgs, Proteus mirabilisg+wgs+gi, Proteus vulgariswgs, Providencia rettgerip+wgs, Pseudomonas aeruginosawgs, Salmonella entericag+p+wgs+gi, Serratia liquefacienswgs, Serratia marcescensg+wgs, Shigella boydiiwgs, Shigella dysenteriaeg+p+wgs+gi, Shigella flexnerig+p+wgs+gi, Shigella sonneiwgs, Streptococcus agalactiaeg, Streptococcus mutansp, Vibrio choleraep, Vibrio parahaemolyticuswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs+gi, Aeromonas caviaeg+wgs, Aeromonas hydrophilag+p, Alcaligenes faecaliswgs, Bacillus cereuswgs, Bacillus thuringiensiswgs, Burkholderia malleiwgs, Citrobacter freundiig+p+wgs, Citrobacter koseriwgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniiwgs, Comamonas testosteroniwgs, Cronobacter sakazakiiwgs, Cupriavidus metalliduranswgs, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiip+wgs, Enterococcus faecaliswgs, Escherichia albertiig, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Helicobacter pylorig, Klebsiella aerogeneswgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Legionella pneumophilawgs, Listeria monocytogeneswgs, Morganella morganiig+wgs, Neisseria gonorrhoeaewgs, Proteus mirabilisg+wgs+gi, Proteus vulgariswgs, Providencia rettgerip+wgs, Pseudomonas aeruginosawgs, Pseudomonas putidawgs, Salmonella entericag+p+wgs+gi, Serratia liquefacienswgs, Serratia marcescensg+wgs, Shigella boydiiwgs, Shigella dysenteriaeg+p+wgs+gi, Shigella flexnerig+p+wgs+gi, Shigella sonneiwgs, Staphylococcus aureuswgs, Streptococcus agalactiaeg, Streptococcus mutansp, Vibrio choleraep+wgs, Vibrio parahaemolyticuswgs, Yersinia pestiswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Alton NK and Vapnek D. 1979. Nature 282(5741): 864-869. Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9. (PMID 390403) Elisha BG, et al. 1991. Plasmid 25(2): 96-104. Identification of an Acinetobacter baumannii gene region with sequence and organizational similarity to Tn2670. (PMID 1650008) |
Prevalence of catA1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 4.07% | 0.05% | 1.77% | 2.52% |
| Aeromonas caviae | 2.27% | 0% | 1.08% | 0% |
| Aeromonas hydrophila | 1.54% | 1.3% | 0% | 0% |
| Alcaligenes faecalis | 0% | 0% | 2.94% | 0% |
| Bacillus cereus | 0% | 0% | 0.1% | 0% |
| Bacillus thuringiensis | 0% | 0% | 0.17% | 0% |
| Burkholderia mallei | 0% | 0% | 1.19% | 0% |
| Citrobacter freundii | 1.64% | 0.62% | 3.48% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 3.7% | 0% | 5.41% | 0% |
| Citrobacter werkmanii | 0% | 0% | 12.82% | 0% |
| Comamonas testosteroni | 0% | 0% | 7.14% | 0% |
| Cronobacter sakazakii | 0% | 0% | 0.22% | 0% |
| Cupriavidus metallidurans | 0% | 0% | 11.11% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 5.53% | 0% |
| Enterobacter cloacae | 0% | 2.79% | 5.75% | 0% |
| Enterobacter hormaechei | 0% | 1.35% | 7.47% | 0% |
| Enterobacter kobei | 0% | 0% | 7.42% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 3.6% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.04% | 0% |
| Escherichia albertii | 1.43% | 0% | 0% | 0% |
| Escherichia coli | 2.43% | 0.47% | 4.29% | 0.64% |
| Escherichia fergusonii | 0% | 0.36% | 1.09% | 0% |
| Helicobacter pylori | 1.03% | 0% | 0% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 0% |
| Klebsiella michiganensis | 8.06% | 0% | 1.06% | 0% |
| Klebsiella oxytoca | 2.56% | 0% | 9.24% | 0% |
| Klebsiella pneumoniae | 0.83% | 2.23% | 11.28% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 6.45% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 2.33% | 0% |
| Legionella pneumophila | 0% | 0% | 0.22% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.05% | 0% |
| Morganella morganii | 23.08% | 0% | 9.82% | 0% |
| Neisseria gonorrhoeae | 0% | 0% | 0.22% | 0% |
| Proteus mirabilis | 18.35% | 0% | 7.92% | 3.7% |
| Proteus vulgaris | 0% | 0% | 5.56% | 0% |
| Providencia rettgeri | 0% | 5.41% | 1.27% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.09% | 0% |
| Pseudomonas putida | 0% | 0% | 0.53% | 0% |
| Salmonella enterica | 2.02% | 1.64% | 3.77% | 7.95% |
| Serratia liquefaciens | 0% | 0% | 3.17% | 0% |
| Serratia marcescens | 0.76% | 0% | 1.83% | 0% |
| Shigella boydii | 0% | 0% | 6.67% | 0% |
| Shigella dysenteriae | 21.43% | 13.64% | 30% | 25% |
| Shigella flexneri | 45% | 0.4% | 68.48% | 16.67% |
| Shigella sonnei | 0% | 0% | 7.52% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.01% | 0% |
| Streptococcus agalactiae | 0.93% | 0% | 0% | 0% |
| Streptococcus mutans | 0% | 33.33% | 0% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.06% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
| Yersinia pestis | 0% | 0% | 0.2% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400