| Accession | ARO:3002684 |
| CARD Short Name | catII |
| Definition | catII is a plasmid-encoded variant of the cat gene found in Haemophilus influenzae, Agrobacterium tumefaciens and Escherichia coli. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas caviaeg+wgs, Aeromonas veroniiwgs, Avibacterium paragallinarumg+wgs+gi, Escherichia colip+wgs, Haemophilus influenzaewgs, Klebsiella aerogeneswgs, Klebsiella huaxiensisgi, Klebsiella pneumoniaewgs, Morganella morganiig+wgs, Pasteurella multocidag+wgs, Proteus mirabiliswgs, Proteus pennerig, Providencia rettgerig, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Salmonella entericawgs+gi |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Murray IA, et al. 1990. Biochem J 272(2): 505-510. Nucleotide sequences of genes encoding the type II chloramphenicol acetyltransferases of Escherichia coli and Haemophilus influenzae, which are sensitive to inhibition by thiol-reactive reagents. (PMID 2268278) |
Prevalence of catII among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.03% | 0% |
| Aeromonas caviae | 2.27% | 0% | 0.54% | 0% |
| Aeromonas veronii | 0% | 0% | 0.56% | 0% |
| Avibacterium paragallinarum | 18.75% | 0% | 2.94% | 50% |
| Escherichia coli | 0% | 0.01% | 0.01% | 0% |
| Haemophilus influenzae | 0% | 0% | 0.94% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.56% | 0% |
| Klebsiella huaxiensis | 0% | 0% | 0% | 50% |
| Klebsiella pneumoniae | 0% | 0% | 0.1% | 0% |
| Morganella morganii | 23.08% | 0% | 10.43% | 0% |
| Pasteurella multocida | 1.43% | 0% | 1.5% | 0% |
| Proteus mirabilis | 0% | 0% | 0.33% | 0% |
| Proteus penneri | 50% | 0% | 0% | 0% |
| Providencia rettgeri | 2.94% | 0% | 0% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0.99% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400