| Accession | ARO:3002685 |
| Synonym(s) | catA3 |
| CARD Short Name | catIII |
| Definition | catIII is a plasmid-encoded variant of the cat gene found in Shigella flexneri. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Escherichia coliwgs, Klebsiella pneumoniaewgs, Providencia stuartiig+wgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Resistomes with Sequence Variants | Actinobacillus indolicusg+gi, Avibacterium paragallinarumwgs, Escherichia colip+wgs, Glaesserella parasuisg+wgs, Klebsiella pneumoniaewgs, Pasteurella multocidag+wgs+gi, Providencia stuartiig+wgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + phenicol antibiotic [Drug Class] + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Murray IA, et al. 1988. Biochem J 252(1): 173-179. Nucleotide sequence analysis and overexpression of the gene encoding a type III chloramphenicol acetyltransferase. (PMID 3048245) |
Prevalence of catIII among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Actinobacillus indolicus | 100% | 0% | 0% | 100% |
| Avibacterium paragallinarum | 0% | 0% | 2.94% | 0% |
| Escherichia coli | 0% | 0.01% | 0.01% | 0% |
| Glaesserella parasuis | 9.09% | 0% | 4.17% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.02% | 0% |
| Pasteurella multocida | 2.25% | 0% | 0.53% | 16.67% |
| Providencia stuartii | 100% | 0% | 58.14% | 0% |
| Vibrio cholerae | 0% | 0% | 0.07% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.06% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 400