| Accession | ARO:3002686 |
| CARD Short Name | catP |
| Definition | catP is a transposon and chromosome-encoded variant of the cat gene found in Clostridium perfringens and Neisseria meningitidis. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Avibacterium paragallinarumg+wgs, Faecalibacterium prausnitziig, Haemophilus influenzaewgs, Neisseria meningitidiswgs, Pasteurella multocidag+gi, Streptococcus agalactiaeg+wgs, Streptococcus pyogeneswgs, Streptococcus suisg |
| Resistomes with Sequence Variants | Avibacterium paragallinarumg+wgs, Faecalibacterium prausnitziig, Haemophilus influenzaewgs, Neisseria meningitidiswgs, Pasteurella multocidag+gi, Streptococcus agalactiaeg+wgs, Streptococcus pyogeneswgs, Streptococcus suisg |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + phenicol antibiotic [Drug Class] + antibiotic inactivation enzyme + acylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Bannam TL, et al. 1995. Mol Microbiol 16(3): 535-551. Molecular genetics of the chloramphenicol-resistance transposon Tn4451 from Clostridium perfringens: the TnpX site-specific recombinase excises a circular transposon molecule. (PMID 7565113) Galimand M, et al. 1998. N Engl J Med 339(13): 868-874. High-level chloramphenicol resistance in Neisseria meningitidis. (PMID 9744970) |
Prevalence of catP among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Avibacterium paragallinarum | 6.25% | 0% | 2.94% | 0% |
| Faecalibacterium prausnitzii | 13.33% | 0% | 0% | 0% |
| Haemophilus influenzae | 0% | 0% | 0.13% | 0% |
| Neisseria meningitidis | 0% | 0% | 0.37% | 0% |
| Pasteurella multocida | 1.43% | 0% | 0% | 33.33% |
| Streptococcus agalactiae | 0.93% | 0% | 0.13% | 0% |
| Streptococcus pyogenes | 0% | 0% | 0.05% | 0% |
| Streptococcus suis | 0.8% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400