Accession ARO:3002700
CARD Short Namecmlv
Definitioncmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae.
AMR Gene Familychloramphenicol phosphotransferase
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ chloramphenicol phosphotransferase [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Publications

Mosher RH, et al. 1995. J Biol Chem 270(45): 27000-27006. Inactivation of chloramphenicol by O-phosphorylation. A novel resistance mechanism in Streptomyces venezuelae ISP5230, a chloramphenicol producer. (PMID 7592948)

Resistomes

Prevalence of cmlv among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 700


>gb|AAB36568.1|+|cmlv [Streptomyces venezuelae ATCC 10712]
MPSPSAEPTTSTPTPDAGPAASPRMPLAVYILGLSAFALGTSEFMLSGLVPPIAEDMNVSIPRAGLLISAFAIGMVVGAPLLAVATLRLP
RKTTLIALITVFGLRQMAGALAPNYAVLFASRVISALPCAGFWAVGAAVAIAMVPVGSRARALAVMIGGLSIANVLRVPAGAFLGEHLGW
ASAFWAVGLASAIALVGVVTRIPRIPLPETRPRPLKNEVAIYRDRQVLLSIAVTALAAGGVFCAFSYLAPLLTDVSGLDEAWVSGVLGLF
GIGAVVGTTIGGRVADAHLFGVLLTGISASTVFLVALALFASNPAATIVLTFLLGVSAFYTAPALNARMFNVAGAAPTLAGATTTAAFNL
GNTGGPWLGGTVIDANLGFASTAWAGAAMTVLGLGTAALALRLTKRPAPGHVVARSRGAGGTTPSEPARGKATSSC


>gb|U09991.1|+|28-1338|cmlv [Streptomyces venezuelae ATCC 10712]
ATGCCGTCTCCCTCCGCCGAGCCCACGACATCCACCCCGACCCCCGACGCCGGGCCCGCCGCATCCCCCCGGATGCCCCTGGCCGTCTAC
ATCCTCGGACTGTCCGCGTTCGCGCTCGGGACGAGCGAATTCATGCTCTCCGGCCTCGTGCCGCCCATCGCGGAGGACATGAACGTCTCC
ATCCCCCGCGCCGGACTCCTCATCTCGGCGTTCGCGATCGGCATGGTCGTCGGCGCACCGCTCCTCGCCGTCGCCACCCTCCGGCTCCCC
CGCAAGACCACCCTCATCGCCCTCATCACCGTCTTCGGCCTGCGCCAGATGGCCGGCGCCCTCGCCCCCAACTACGCGGTCCTCTTCGCC
TCCCGCGTGATCAGCGCCCTGCCCTGCGCGGGCTTCTGGGCGGTCGGCGCGGCGGTGGCCATCGCGATGGTCCCGGTCGGCTCACGGGCC
CGGGCGCTGGCGGTCATGATCGGCGGCCTCTCCATCGCCAACGTCCTGCGCGTCCCCGCCGGCGCCTTCCTCGGCGAGCACCTCGGCTGG
GCCTCCGCCTTCTGGGCCGTCGGCCTCGCCTCCGCCATCGCGCTCGTCGGCGTCGTCACCCGCATCCCCCGCATCCCGCTCCCCGAGACC
AGGCCCCGCCCTCTCAAGAACGAGGTCGCCATCTACCGCGACCGCCAGGTCCTCCTGTCGATCGCGGTCACGGCCCTCGCGGCGGGCGGC
GTCTTCTGCGCCTTCTCGTACCTCGCGCCGCTGCTCACCGACGTCTCCGGCCTCGACGAGGCCTGGGTCTCCGGCGTCCTCGGCCTCTTC
GGCATCGGCGCCGTCGTCGGTACGACGATCGGCGGCCGGGTCGCCGACGCGCACCTCTTCGGCGTGCTGCTCACCGGCATCTCCGCCTCC
ACCGTCTTCCTCGTGGCCCTGGCCCTGTTCGCCTCGAACCCGGCCGCCACGATCGTGCTGACCTTCCTCCTCGGCGTCTCGGCCTTCTAC
ACGGCCCCGGCCCTCAACGCCCGCATGTTCAACGTCGCCGGCGCCGCCCCCACCCTCGCGGGCGCCACCACCACCGCCGCCTTCAACCTC
GGCAACACGGGCGGCCCCTGGCTCGGCGGCACGGTCATCGACGCGAACCTCGGCTTCGCCTCGACGGCCTGGGCGGGCGCGGCGATGACG
GTCCTGGGCCTGGGAACGGCGGCCCTGGCCCTCCGCCTGACCAAGCGCCCGGCCCCCGGCCACGTGGTCGCCCGGAGCAGAGGGGCGGGC
GGGACCACCCCGTCCGAACCGGCCAGGGGGAAGGCCACGTCGAGCTGCTGA