Accession ARO:3002700
Definitioncmlv is a chromosome-encoded chloramphenicol phoshotransferase that is found in Streptomyces venezuelae
AMR Gene Familychloramphenicol phosphotransferase
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ chloramphenicol phosphotransferase [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Publications

Mosher RH, et al. 1995. J Biol Chem 270(45): 27000-27006. Inactivation of chloramphenicol by O-phosphorylation. A novel resistance mechanism in Streptomyces venezuelae ISP5230, a chloramphenicol producer. (PMID 7592948)

Resistomes

Prevalence of cmlv among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 700


>gb|AAB36568.1|+|cmlv [Streptomyces venezuelae ATCC 10712]
MPSPSAEPTTSTPTPDAGPAASPRMPLAVYILGLSAFALGTSEFMLSGLVPPIAEDMNVSIPRAGLLISAFAIGMVVGAPLLAVATLRLP
RKTTLIALITVFGLRQMAGALAPNYAVLFASRVISALPCAGFWAVGAAVAIAMVPVGSRARALAVMIGGLSIANVLRVPAGAFLGEHLGW
ASAFWAVGLASAIALVGVVTRIPRIPLPETRPRPLKNEVAIYRDRQVLLSIAVTALAAGGVFCAFSYLAPLLTDVSGLDEAWVSGVLGLF
GIGAVVGTTIGGRVADAHLFGVLLTGISASTVFLVALALFASNPAATIVLTFLLGVSAFYTAPALNARMFNVAGAAPTLAGATTTAAFNL
GNTGGPWLGGTVIDANLGFASTAWAGAAMTVLGLGTAALALRLTKRPAPGHVVARSRGAGGTTPSEPARGKATSSC


>gb|U09991|+|28-1338|cmlv [Streptomyces venezuelae ATCC 10712]
ATGCCGTCTCCCTCCGCCGAGCCCACGACATCCACCCCGACCCCCGACGCCGGGCCCGCCGCATCCCCCCGGATGCCCCTGGCCGTCTAC
ATCCTCGGACTGTCCGCGTTCGCGCTCGGGACGAGCGAATTCATGCTCTCCGGCCTCGTGCCGCCCATCGCGGAGGACATGAACGTCTCC
ATCCCCCGCGCCGGACTCCTCATCTCGGCGTTCGCGATCGGCATGGTCGTCGGCGCACCGCTCCTCGCCGTCGCCACCCTCCGGCTCCCC
CGCAAGACCACCCTCATCGCCCTCATCACCGTCTTCGGCCTGCGCCAGATGGCCGGCGCCCTCGCCCCCAACTACGCGGTCCTCTTCGCC
TCCCGCGTGATCAGCGCCCTGCCCTGCGCGGGCTTCTGGGCGGTCGGCGCGGCGGTGGCCATCGCGATGGTCCCGGTCGGCTCACGGGCC
CGGGCGCTGGCGGTCATGATCGGCGGCCTCTCCATCGCCAACGTCCTGCGCGTCCCCGCCGGCGCCTTCCTCGGCGAGCACCTCGGCTGG
GCCTCCGCCTTCTGGGCCGTCGGCCTCGCCTCCGCCATCGCGCTCGTCGGCGTCGTCACCCGCATCCCCCGCATCCCGCTCCCCGAGACC
AGGCCCCGCCCTCTCAAGAACGAGGTCGCCATCTACCGCGACCGCCAGGTCCTCCTGTCGATCGCGGTCACGGCCCTCGCGGCGGGCGGC
GTCTTCTGCGCCTTCTCGTACCTCGCGCCGCTGCTCACCGACGTCTCCGGCCTCGACGAGGCCTGGGTCTCCGGCGTCCTCGGCCTCTTC
GGCATCGGCGCCGTCGTCGGTACGACGATCGGCGGCCGGGTCGCCGACGCGCACCTCTTCGGCGTGCTGCTCACCGGCATCTCCGCCTCC
ACCGTCTTCCTCGTGGCCCTGGCCCTGTTCGCCTCGAACCCGGCCGCCACGATCGTGCTGACCTTCCTCCTCGGCGTCTCGGCCTTCTAC
ACGGCCCCGGCCCTCAACGCCCGCATGTTCAACGTCGCCGGCGCCGCCCCCACCCTCGCGGGCGCCACCACCACCGCCGCCTTCAACCTC
GGCAACACGGGCGGCCCCTGGCTCGGCGGCACGGTCATCGACGCGAACCTCGGCTTCGCCTCGACGGCCTGGGCGGGCGCGGCGATGACG
GTCCTGGGCCTGGGAACGGCGGCCCTGGCCCTCCGCCTGACCAAGCGCCCGGCCCCCGGCCACGTGGTCGCCCGGAGCAGAGGGGCGGGC
GGGACCACCCCGTCCGAACCGGCCAGGGGGAAGGCCACGTCGAGCTGCTGA