BcI

Accession ARO:3002877
CARD Short NameBcI
DefinitionBacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9.
AMR Gene Familyclass A Bacillus cereus Bc beta-lactamase
Drug Classpenem, cephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesBacillus cereuswgs
Resistomes with Sequence VariantsBacillus amyloliquefaciensg+wgs, Bacillus anthracisg+wgs, Bacillus cereusg+wgs, Bacillus halotoleransg+wgs, Bacillus subtilisg+wgs, Bacillus tequilensisg+wgs, Bacillus thuringiensisg+wgs, Bacillus velezensisg+p+wgs, Brevibacillus brevisg+wgs
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Torkar KG, et al. 2018. Microb Pathog 118:140-145 Antimicrobial susceptibility and characterization of metallo-β-lactamases, extended-spectrum β-lactamases, and carbapenemases of Bacillus cereus isolates. (PMID 29551437)

Resistomes

Prevalence of BcI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacillus amyloliquefaciens100%0%83.15%0%
Bacillus anthracis3.28%0%6.58%0%
Bacillus cereus98.92%0%83.55%0%
Bacillus halotolerans9.09%0%16.22%0%
Bacillus subtilis87.46%0%66.47%0%
Bacillus tequilensis100%0%100%0%
Bacillus thuringiensis95%0%89.53%0%
Bacillus velezensis98.66%0.9%83.15%0%
Brevibacillus brevis100%0%100%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 350


>gb|CAA29819.1|+|BcI [Bacillus cereus]
MKNKRMLKIGICVGILGLSITSLEAFTGESLQVEAKEKTGQVKHKNQATHKEFSQLEKKFDARLGVYAIDTGTNQTISYRPNERFAFAST
YKALAAGVLLQQNSIDSLNEVITYTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGGPKGYEKALRHMGDRITMSN
RFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEKRKILTEWMKGNATGDKLIRAGIPTDWVVGDKSGAGSYGTRNDIAVVWPPN
RAPIIIAILSSKDEKEAIYDNQLIAEATKVIVKALR


>gb|X06599.1|+|273-1193|BcI [Bacillus cereus]
TTGAAAAATAAGAGGATGCTAAAAATAGGAATATGCGTTGGTATATTAGGTTTAAGTATTACAAGCCTAGAAGCTTTTACAGGAGAGTCA
CTGCAAGTTGAAGCGAAAGAAAAGACTGGACAAGTGAAACACAAAAATCAGGCAACGCATAAAGAGTTCTCTCAACTTGAGAAAAAATTT
GATGCTCGATTAGGTGTATATGCGATTGATACTGGTACAAATCAAACAATCTCTTATCGACCTAACGAAAGATTTGCCTTCGCATCAACA
TACAAGGCTTTAGCCGCGGGAGTATTACTACAGCAAAACTCAATTGATTCATTAAATGAAGTAATCACATATACGAAAGAAGACTTAGTG
GATTATTCACCTGTTACAGAGAAACATGTAGATACTGGAATGAAACTAGGAGAAATTGCAGAGGCAGCTGTTCGTTCAAGTGATAATACT
GCAGGGAACATTTTATTTAATAAAATAGGAGGACCGAAAGGATATGAAAAAGCGCTTAGGCATATGGGGGATCGGATTACTATGTCTAAT
CGCTTTGAAACAGAATTAAACGAAGCTATTCCAGGAGACATTCGTGACACTAGTACAGCGAAAGCTATTGCTACGAATCTTAAAGCTTTT
ACGGTCGGAAATGCACTTCCAGCTGAAAAACGTAAAATTCTTACAGAGTGGATGAAAGGAAATGCTACAGGGGACAAACTTATTCGTGCA
GGCATACCAACTGACTGGGTAGTTGGAGATAAATCAGGTGCTGGTAGTTACGGGACAAGAAATGATATTGCTGTCGTTTGGCCTCCAAAT
AGAGCACCAATTATCATCGCAATTTTATCTAGTAAAGATGAGAAAGAGGCAATCTATGATAATCAACTCATTGCAGAGGCAACTAAAGTT
ATAGTTAAGGCTCTTAGGTAA