mexM

Accession ARO:3003704
DefinitionmexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, antibacterial free fatty acids, phenicol antibiotic, aminocoumarin antibiotic, diaminopyrimidine antibiotic, penam, aminoglycoside antibiotic, carbapenem, monobactam, triclosan, glycylcycline, fluoroquinolone antibiotic, acridine dye, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification25 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Mima T, et al. 2009. Microbiology (Reading, Engl.) 155(Pt 11):3509-17 Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. (PMID 19713238)

Resistomes

Prevalence of mexM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0%0%0%
Klebsiella pneumoniae0%0%0%
Morganella morganii0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 650


>gb|BAE06005.1|+|mexM [Pseudomonas aeruginosa]
MQALRSGGGRVLVGVLAAGLVAFGGWAWLGGDAGAKAAPAPARVPVIVARVERRDVEQQVSGIGTVTSLHNVVIRTQIDGQLTRLLVSEG
QMVEAGELLATIDDRAVVAALEQAQASRASNQAQLKSAEQDLQRYRSLYAERAVSRQLLDQQQATVDQLRATLKANDATINAERVRLSYT
RITSPVSGKVGIRNVDVGNLVRVGDSLGLFSVTQIAPISVVFSLQQEQLLQLQALLGGEAAVRAYSRDGGSALGEGRLLTIDNQIDSSTG
TIRVRASFDNRQARLWPGQFVAVSLHTGVRRDQLVLSSKAVRRGLEGNFVYRVADDRVEAVPVRVLQDIDGLSVVEGLASGDQVVVDGHS
RLMPGALVDIQEPRPSLAQATERRP


>gb|AB219523.1|+|22-1179|mexM [Pseudomonas aeruginosa]
ATGCAGGCGTTGCGCAGTGGTGGGGGACGGGTCCTGGTGGGCGTGCTGGCGGCGGGCCTGGTCGCCTTCGGCGGTTGGGCATGGCTCGGC
GGCGACGCCGGGGCGAAGGCGGCGCCCGCGCCGGCCAGGGTCCCGGTGATCGTGGCGCGGGTGGAGCGGCGCGACGTCGAGCAACAGGTC
AGCGGCATCGGCACGGTGACTTCGTTGCACAACGTGGTGATCCGCACCCAGATCGACGGCCAGTTGACCCGCCTGCTGGTGAGCGAAGGG
CAGATGGTCGAGGCGGGCGAGTTACTGGCGACCATCGATGACCGCGCCGTCGTCGCCGCGCTGGAGCAGGCGCAGGCCTCCAGGGCGAGC
AACCAGGCCCAGCTGAAATCCGCCGAGCAGGACCTGCAACGCTACCGCAGCCTGTATGCCGAGCGTGCGGTGTCACGCCAACTGCTGGAC
CAGCAGCAGGCGACGGTCGACCAGTTGCGCGCGACCCTGAAGGCCAACGATGCCACCATCAACGCCGAGCGGGTGCGCCTGTCCTACACC
CGGATCACCTCGCCGGTATCCGGCAAGGTCGGTATCCGCAACGTCGATGTCGGCAACCTGGTGCGGGTCGGCGACAGTCTCGGCCTGTTC
AGCGTGACCCAGATCGCACCGATCTCCGTAGTCTTCTCCCTGCAACAGGAACAGTTGCTCCAGTTGCAGGCGCTGCTCGGCGGCGAGGCG
GCGGTGCGCGCCTACAGCCGCGACGGCGGGAGCGCGCTGGGCGAGGGCCGGTTGCTGACCATCGACAACCAGATCGACAGTTCCACCGGC
ACCATCCGCGTGCGCGCCTCCTTCGATAACCGCCAGGCCCGGCTCTGGCCCGGGCAGTTCGTCGCGGTGAGCCTGCACACCGGGGTCCGG
CGCGACCAGTTGGTGCTGTCGAGCAAGGCGGTGCGCCGCGGCCTGGAGGGCAATTTCGTCTACCGGGTCGCCGACGACCGGGTCGAGGCG
GTGCCGGTGCGGGTGCTCCAGGACATCGACGGCCTCAGTGTGGTGGAAGGCCTGGCCAGCGGTGACCAGGTGGTGGTGGACGGCCACTCG
CGGCTGATGCCCGGCGCCCTGGTCGATATCCAGGAGCCGCGCCCGAGCCTGGCCCAGGCCACGGAGCGGCGGCCGTGA