CatU

Accession ARO:3003983
DefinitionChloramphenicol acetyltransferase conferring resistance to phenicol antibiotics detected in Paenibacillus sp. LC231, an isolated strain of Paenibacillus from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016.
AMR Gene Familychloramphenicol acetyltransferase (CAT)
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ chloramphenicol acetyltransferase (CAT) [AMR Gene Family]
+ confers_resistance_to_antibiotic azidamfenicol [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic thiamphenicol [Antibiotic]
Publications

Pawlowski AC, et al. 2016. Nat Commun 7:13803 A diverse intrinsic antibiotic resistome from a cave bacterium. (PMID 27929110)

Resistomes

Prevalence of CatU among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 400

Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded


>gb|APB03217.1|+|CatU [Paenibacillus sp. LC231]
MKFHIINVEEWTRKPYYEHYLRSNKCTFSITVDIDITRLLYSLKANGFKLYPAFIYMVTRVVNDRVEFKTSFSPEGELGYWDRMTPSYTF
FHNDDHTFSCLWTAFSNDFYRFHDHYEQDMEQYRDTKGLFVKENPPPNTFPISMIPWTSFSGFNLNIVNEADYLLPIITGGKYTEQGGRV
LLPVSLQVHHAVCDGYHASMFFKELQSLADSFEDWLT


>gb|KX531047.1|+|1-654|CatU [Paenibacillus sp. LC231]
ATGAAGTTTCACATTATTAATGTTGAAGAGTGGACGAGAAAGCCTTATTATGAGCATTATCTTCGATCGAATAAATGCACCTTCAGCATC
ACCGTGGATATCGACATTACTCGCTTGTTGTATTCGTTAAAAGCTAATGGATTCAAGCTTTATCCAGCTTTTATTTATATGGTTACAAGA
GTTGTCAATGACCGGGTTGAATTCAAAACTTCCTTTAGTCCCGAAGGGGAATTGGGTTACTGGGATCGGATGACGCCGAGTTATACCTTT
TTCCATAACGATGACCATACCTTCTCCTGTTTATGGACAGCATTTTCGAATGATTTCTATCGATTTCATGATCATTACGAGCAGGACATG
GAGCAATATCGGGATACAAAAGGGCTGTTTGTTAAAGAGAATCCACCGCCGAACACGTTTCCCATATCCATGATACCCTGGACAAGCTTT
AGCGGATTTAATCTAAACATTGTCAATGAAGCAGACTATCTTCTTCCCATCATAACCGGCGGAAAATATACCGAGCAGGGTGGCCGTGTT
CTGCTTCCAGTCTCATTGCAGGTGCACCATGCTGTGTGTGATGGTTATCATGCCAGCATGTTCTTTAAGGAGTTGCAGAGCTTGGCGGAT
TCTTTTGAAGATTGGTTAACTTAA