cpaA

Accession ARO:3003994
CARD Short NamecpaA
DefinitioncpaA is a capreomycin acetyltransferase protein found in Paenibacillus sp. LC231, an isolated strain of Paenibacillus in Lechuguilla Cave, NM, USA. Confers resistance to capreomycin, an aminoglycoside antibiotic. Described by Pawlowski et al. 2016.
AMR Gene Familycpa acetyltransferase
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic capreomycin [Antibiotic]
+ cpa acetyltransferase [AMR Gene Family]
Publications

Pawlowski AC, et al. 2016. Nat Commun 7:13803 A diverse intrinsic antibiotic resistome from a cave bacterium. (PMID 27929110)

Resistomes

Prevalence of cpaA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 300

Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded


>gb|APB03224.1|+|cpaA [Paenibacillus sp. LC231]
MPLRITAMTETYADQIMQWSYEPPYDFYNSEPDEEFRKELLECSYYAILDKEGQLFGFCCTGSSAQIPIAIPLGAYDEDLLDFGLGMKPE
STGQCRGKEFLSFVLASIAEFHKRQSFRLTVAKFNERAIRLYTQLGFSEVATFDYGGTTFITMIKKPGSGL


>gb|KX531054.1|+|1-486|cpaA [Paenibacillus sp. LC231]
ATGCCTCTTCGTATCACGGCCATGACCGAAACGTATGCCGATCAAATTATGCAATGGAGCTATGAACCTCCCTATGATTTCTACAACAGC
GAACCGGATGAGGAGTTTCGGAAAGAACTTCTGGAGTGCTCGTATTACGCCATACTGGACAAGGAAGGGCAGCTCTTCGGCTTTTGCTGT
ACAGGCTCATCAGCCCAAATTCCGATCGCAATCCCGTTAGGTGCATATGACGAGGATCTGCTGGATTTCGGACTTGGGATGAAACCGGAA
TCGACCGGACAATGCCGGGGAAAAGAGTTTCTCTCGTTCGTGCTGGCATCCATCGCTGAATTTCACAAGCGCCAATCGTTTCGGCTGACC
GTTGCCAAATTCAATGAACGAGCCATTCGCTTGTATACCCAGCTGGGCTTCTCGGAAGTTGCAACGTTTGATTATGGCGGCACTACGTTC
ATAACGATGATCAAGAAGCCGGGCTCCGGATTGTAA