cepA beta-lactamase [AMR Gene Family]

Accession ARO:3004192
DefinitioncepA beta-lactamases are Class A beta-lactamases found in Bateroides fragilis and have the ability to hydrolyze cephalosporin.
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ class A beta-lactamase
1 ontology terms | Show
+ cepA

Rogers MB, et al. 1994. J Bacteriol 176(14): 4376-4384. Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates. (PMID 7517394)

Rogers MB, et al. 1993. Antimicrob. Agents Chemother. 37(11):2391-400 Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases. (PMID 8285623)