lipid A acyltransferase [AMR Gene Family]

Accession ARO:3004363
DefinitionLipid A acyltransferase genes confer resistance to certain types of peptide antibiotics such as polymyxins through the aminoacylation of lipopolysaccharide, thereby decreasing the negative charge of the outer membrane surface.
Drug Classpeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
1 ontology terms | Show
+ almG

Henderson JC, et al. 2017. J. Biol. Chem. 292(51):21205-21215 AlmG, responsible for polymyxin resistance in pandemic, is a glycyltransferase distantly related to lipid A late acyltransferases. (PMID 29101229)