| Accession | ARO:3004455 |
| CARD Short Name | Ssui_ACT_CHL |
| Definition | A chloramphenicol resistance determinant described in Streptococcus suis. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Streptococcus pyogenesg+wgs, Streptococcus suiswgs |
| Resistomes with Sequence Variants | Aliarcobacter butzlerig+p, Bacillus subtilisg+p+wgs, Campylobacter colig+wgs, Campylobacter jejunig+p+wgs, Enterococcus faecaliswgs, Enterococcus faeciump+wgs, Jeotgalibaca porcig, Serratia marcescenswgs, Staphylococcus aureusg+p+wgs, Staphylococcus epidermidisg+p, Staphylococcus hominisp, Staphylococcus pseudintermediuswgs, Streptococcus agalactiaeg+wgs, Streptococcus anginosuswgs, Streptococcus gallolyticuswgs, Streptococcus gordoniiwgs, Streptococcus lutetiensiswgs, Streptococcus mitisg+wgs, Streptococcus pneumoniaeg+wgs, Streptococcus pyogenesg+wgs, Streptococcus suisg+wgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance |
| Parent Term(s) | 2 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] |
| Publications | Takamatsu D, et al. 2003. Plasmid 49(2): 143-151. Chloramphenicol resistance transposable element TnSs1 of Streptococcus suis, a transposon flanked by IS6-family elements. (PMID 12726767) |
Prevalence of Streptococcus suis chloramphenicol acetyltransferase among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aliarcobacter butzleri | 12.5% | 33.33% | 0% | 0% |
| Bacillus subtilis | 4.3% | 0.63% | 0.58% | 0% |
| Campylobacter coli | 10.14% | 0% | 0.44% | 0% |
| Campylobacter jejuni | 2.11% | 0.99% | 0.23% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.12% | 0% |
| Enterococcus faecium | 0% | 0.26% | 1.19% | 0% |
| Jeotgalibaca porci | 100% | 0% | 0% | 0% |
| Serratia marcescens | 0% | 0% | 0.26% | 0% |
| Staphylococcus aureus | 0.09% | 0.22% | 0.14% | 0% |
| Staphylococcus epidermidis | 0.65% | 0.58% | 0% | 0% |
| Staphylococcus hominis | 0% | 2.08% | 0% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 0.26% | 0% |
| Streptococcus agalactiae | 1.87% | 0% | 0.58% | 0% |
| Streptococcus anginosus | 0% | 0% | 0.58% | 0% |
| Streptococcus gallolyticus | 0% | 0% | 2.27% | 0% |
| Streptococcus gordonii | 0% | 0% | 1.28% | 0% |
| Streptococcus lutetiensis | 0% | 0% | 2.04% | 0% |
| Streptococcus mitis | 11.11% | 0% | 0.51% | 0% |
| Streptococcus pneumoniae | 8.74% | 0% | 5.15% | 0% |
| Streptococcus pyogenes | 0.37% | 0% | 0.15% | 0% |
| Streptococcus suis | 1.6% | 0% | 1.78% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 350