Glycosylation [Virulence Mechanism]

Accession VIRO:0000316
DefinitionMechanism for intracellularly active bacterial toxins that target rho proteins in order to ultimately affect actin polymerization within host cells as a toxic effect. Involves the addition of a glucose molecule to a protein residue in order to inactivate the target protein. Conventional acceptor amino acids that act as glycosyl-acceptors includes serine, threonine and asparagine. Unconventional glycosyl-acceptor amino acids includes tyrosine, tryptophan and arginine. Generally results in the inhibition of actin polymerization within the host cells.
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show

Jank T, et al. 2013. Nat. Struct. Mol. Biol. 20(11):1273-80 A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. (PMID 24141704)

Just I, et al. 1995. Nature 375(6531):500-3 Glucosylation of Rho proteins by Clostridium difficile toxin B. (PMID 7777059)