catA4

Accession ARO:3004657
CARD Short NamecatA4
DefinitioncatA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol.
AMR Gene Familychloramphenicol acetyltransferase (CAT)
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsProteus mirabilisg+wgs
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ chloramphenicol acetyltransferase (CAT) [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Publications

Charles IG, et al. 1985. J Bacteriol 164(1): 123-129. Nucleotide sequence analysis of the cat gene of Proteus mirabilis: comparison with the type I (Tn9) cat gene. (PMID 3900035)

Resistomes

Prevalence of catA4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Escherichia coli0%0%0%0%
Proteus mirabilis93.58%0%40.92%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AAA25655.1|+|catA4 [Proteus mirabilis]
MDTKRVGILVVDLSQWGRKEHFEAFQSFAQCTFSQTVQLDITSLLKTVKQNGYKFYPTFIYIISLLVNKHAEFRMAMKDGELVIWDSVNP
GYNIFHEQTETFSSLWSYYHKDINRFLKTYSEDIAQYGDDLAYFPKEFIENMFFVSANPWVSFTSFNLNMANINNFFAPVFTIGKYYTQG
DKVLMPLAIQVHHAVCDGFHVGRLLNEIQQYCDEGCK


>gb|M11587.1|+|880-1533|catA4 [Proteus mirabilis]
ATGGACACAAAGCGCGTGGGTATATTGGTTGTTGATCTATCCCAATGGGGACGAAAAGAACACTTTGAAGCATTTCAGTCTTTTGCTCAA
TGCACCTTTAGCCAGACCGTTCAACTGGATATTACTTCATTATTAAAAACCGTAAAGCAAAATGGGTACAAATTCTATCCGACATTTATA
TACATCATTAGCCTATTGGTAAATAAACATGCAGAATTCCGCATGGCAATGAAAGACGGGGAATTGGTGATATGGGATAGTGTTAACCCT
GGGTACAATATCTTTCATGAACAGACCGAAACATTTTCATCTTTATGGAGTTACTACCACAAAGATATCAATCGTTTTTTGAAAACTTAT
TCAGAAGATATAGCACAATACGGCGACGATCTAGCCTATTTTCCAAAAGAATTTATCGAAAATATGTTTTTTGTGTCAGCAAATCCTTGG
GTAAGTTTCACCAGTTTTAACTTGAATATGGCGAATATAAACAATTTCTTTGCCCCTGTATTTACAATAGGTAAATATTATACGCAAGGA
GATAAAGTTCTGATGCCACTAGCAATTCAAGTGCATCATGCCGTATGTGATGGCTTCCATGTAGGCAGATTACTCAATGAAATACAGCAA
TACTGCGATGAGGGATGTAAATAA