catA4

Accession ARO:3004657
DefinitioncatA4 is a chloramphenicol acetyltransferase that confers resistance to chloramphenicol.
AMR Gene Familychloramphenicol acetyltransferase (CAT)
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic inactivation
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ chloramphenicol acetyltransferase (CAT) [AMR Gene Family]
+ confers_resistance_to_drug_class chloramphenicol [Antibiotic]
Publications

Charles IG, et al. 1985. J Bacteriol 164(1): 123-129. Nucleotide sequence analysis of the cat gene of Proteus mirabilis: comparison with the type I (Tn9) cat gene. (PMID 3900035)

Resistomes

Prevalence of catA4 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Proteus mirabilis86.96%0%91.38%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 400


>gb|AAA25655.1|+|catA4 [Proteus mirabilis]
MDTKRVGILVVDLSQWGRKEHFEAFQSFAQCTFSQTVQLDITSLLKTVKQNGYKFYPTFIYIISLLVNKHAEFRMAMKDGELVIWDSVNP
GYNIFHEQTETFSSLWSYYHKDINRFLKTYSEDIAQYGDDLAYFPKEFIENMFFVSANPWVSFTSFNLNMANINNFFAPVFTIGKYYTQG
DKVLMPLAIQVHHAVCDGFHVGRLLNEIQQYCDEGCK


>gb|M11587.1|+|880-1533|catA4 [Proteus mirabilis]
ATGGACACAAAGCGCGTGGGTATATTGGTTGTTGATCTATCCCAATGGGGACGAAAAGAACACTTTGAAGCATTTCAGTCTTTTGCTCAA
TGCACCTTTAGCCAGACCGTTCAACTGGATATTACTTCATTATTAAAAACCGTAAAGCAAAATGGGTACAAATTCTATCCGACATTTATA
TACATCATTAGCCTATTGGTAAATAAACATGCAGAATTCCGCATGGCAATGAAAGACGGGGAATTGGTGATATGGGATAGTGTTAACCCT
GGGTACAATATCTTTCATGAACAGACCGAAACATTTTCATCTTTATGGAGTTACTACCACAAAGATATCAATCGTTTTTTGAAAACTTAT
TCAGAAGATATAGCACAATACGGCGACGATCTAGCCTATTTTCCAAAAGAATTTATCGAAAATATGTTTTTTGTGTCAGCAAATCCTTGG
GTAAGTTTCACCAGTTTTAACTTGAATATGGCGAATATAAACAATTTCTTTGCCCCTGTATTTACAATAGGTAAATATTATACGCAAGGA
GATAAAGTTCTGATGCCACTAGCAATTCAAGTGCATCATGCCGTATGTGATGGCTTCCATGTAGGCAGATTACTCAATGAAATACAGCAA
TACTGCGATGAGGGATGTAAATAA