BIC-1

Accession ARO:3004753
CARD Short NameBIC-1
DefinitionBIC-1 is a beta-lactamase conferring resistance to carbapenems that is found in Pseudomonas fluorescens.
AMR Gene FamilyBIC Beta-lactamase
Drug Classcarbapenem
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ BIC Beta-lactamase [AMR Gene Family]
Publications

Girlich D, et al. 2010. Antimicrob. Agents Chemother. 54(1):328-32 Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France. (PMID 19901091)

Resistomes

Prevalence of BIC-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 600


>gb|ADB56658.1|+|BIC-1 [Pseudomonas fluorescens]
MARPSKLALSFSLLLPFLPFTSFAETWPQGDIARQKIVKLEKDFGGRIGVSAIDTGANRTFDFRADERFPLCSSFKGFLAGAVLSHSQQQ
EGLLEKRIDYKNRVMEPHSPISAQHSSTGMTVAQLAAAALQYSDNGATNLLLENVLGGPAGMTTFMRTLGDTTFRLDRWELELNSAIPGD
DRDTSTPHAIARSLQKIALGEALQTAPRQQLVDWLIGNTTGGARIRAGVPVEWVVGDKTGTCGVYGTANDYAVIWPKTSAPIVLAIYTAK
PNKEDKHSDAVIAEVTRAVLESFE


>gb|GQ260093.1|+|1-885|BIC-1 [Pseudomonas fluorescens]
ATGGCACGTCCTTCTAAACTAGCTTTATCATTTTCTCTTCTGTTGCCTTTTTTACCCTTCACCAGCTTCGCTGAAACCTGGCCACAGGGC
GATATCGCCCGACAAAAAATCGTAAAGCTGGAAAAGGATTTTGGTGGGCGGATTGGAGTATCTGCCATCGATACGGGCGCCAATCGAACT
TTTGACTTTCGAGCGGACGAACGTTTCCCTTTATGCAGCTCCTTTAAGGGCTTTCTGGCTGGCGCCGTGCTCTCCCACAGCCAACAGCAG
GAAGGCTTACTGGAGAAACGTATCGACTATAAGAATCGGGTGATGGAACCTCACTCTCCCATCAGCGCACAACATAGTTCGACGGGTATG
ACCGTGGCGCAATTAGCGGCAGCGGCGCTGCAGTACAGCGACAACGGTGCGACAAATTTGCTTCTGGAAAACGTTCTGGGCGGGCCCGCC
GGGATGACGACCTTCATGAGGACCTTAGGCGATACAACGTTTCGCTTAGATCGATGGGAACTCGAACTCAATAGCGCCATTCCGGGCGAC
GATCGAGATACCTCGACCCCCCACGCCATAGCCCGCAGCTTGCAAAAAATAGCGTTGGGTGAGGCGTTGCAAACCGCACCGCGTCAGCAG
CTGGTTGATTGGCTCATCGGAAATACGACAGGTGGAGCGCGGATCCGGGCAGGCGTTCCTGTCGAGTGGGTTGTAGGGGATAAAACGGGC
ACGTGCGGTGTGTACGGCACCGCCAATGATTATGCCGTCATATGGCCAAAAACATCCGCCCCGATTGTCTTGGCGATTTACACCGCGAAA
CCGAACAAGGAGGACAAACATAGCGATGCCGTTATTGCCGAAGTGACCCGTGCCGTTCTGGAAAGCTTTGAATAA