BRO-2

Accession ARO:3004762
CARD Short NameBRO-2
DefinitionBRO-2 is a class A beta-lactamase found in M.catarrhalis.
AMR Gene FamilyBRO Beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesMoraxella catarrhaliswgs
Resistomes with Sequence VariantsMoraxella catarrhaliswgs
Classification12 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ BRO Beta-lactamase [AMR Gene Family]
Publications

Bootsma HJ, et al. 1996. Antimicrob. Agents Chemother. 40(4):966-72 Molecular characterization of the BRO beta-lactamase of Moraxella (Branhamella) catarrhalis. (PMID 8849261)

Resistomes

Prevalence of BRO-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Moraxella catarrhalis0%0%4.66%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 634


>gb|CAA90891.1|+|BRO-2 [Moraxella catarrhalis ATCC 43617]
MMQRRHFLQKTLLALPIIFSGNLLTGCKTNLSDDYLPDDKITNNPNLLQNKLKEILPIWENKFNAKIGMTIIADNGELSSHRGNEYFPVN
STIKAFIASHILLLVDKEKLDLNEKIIIKESDLIEYSPVCKKYFDENKPISISELCEATITLSDNGSANILLDKIGGLTAFNQFLKEIGA
DMVLANNEPLLNRSHYGETSDTAKPIPYTKSLKALIVGNILSNQSKEQLITWLINDKVADNLLRKYLPKNWRIGDKTGTGSESKNIIAVI
WNENNKPYFISLFITQPHDGKSLGFKNQKDEIMAQIGKEIYPFL


>gb|Z54181.1|+|63-1007|BRO-2 [Moraxella catarrhalis ATCC 43617]
ATGATGCAACGCCGTCATTTTTTACAAAAAACCTTATTGGCACTACCTATTATTTTTTCTGGCAATTTATTAACTGGATGTAAAACGAAT
TTGTCTGATGATTATTTGCCCGATGACAAGATAACAAACAATCCAAATTTATTACAAAATAAATTAAAAGAGATATTGCCAATTTGGGAA
AATAAATTTAATGCCAAAATTGGTATGACGATTATTGCTGACAATGGTGAACTATCCAGTCATCGTGGTAATGAATATTTTCCTGTTAAT
AGTACCATTAAAGCCTTTATTGCAAGTCATATATTATTACTTGTAGATAAAGAAAAATTGGATTTAAACGAAAAAATCATCATTAAAGAA
AGCGATTTGATAGAATATTCTCCTGTCTGTAAAAAATACTTTGATGAGAATAAACCAATTTCTATTAGTGAATTGTGCGAAGCTACCATA
ACACTGAGTGATAATGGTTCTGCTAATATCTTGTTGGATAAAATTGGGGGTTTGACTGCATTCAATCAATTTTTGAAAGAGATTGGGGCG
GATATGGTGCTGGCAAATAATGAACCTTTATTAAATCGCTCACATTATGGTGAAACCAGTGATACCGCAAAACCAATTCCTTACACAAAA
AGCCTAAAAGCACTGATTGTAGGCAATATCCTATCCAATCAAAGCAAAGAACAGTTGATAACTTGGCTTATCAACGATAAAGTTGCTGAT
AATTTATTGAGAAAATATTTACCAAAAAATTGGCGAATTGGCGACAAAACAGGCACAGGTAGTGAATCAAAAAATATCATTGCTGTGATT
TGGAATGAAAATAATAAACCTTATTTTATCAGCCTATTTATCACCCAGCCCCATGATGGTAAATCCCTTGGTTTTAAAAATCAAAAAGAT
GAAATAATGGCACAAATTGGTAAAGAAATTTATCCATTTTTATAA