DES-1

Accession ARO:3004780
DefinitionDES-1 is a class A beta-lactamase gene found in Desulfovibrio desulfuricans.
AMR Gene FamilyDES beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class penam [Drug Class]
+ DES beta-lactamase [AMR Gene Family]
Publications

Morin AS, et al. 2002. Antimicrob. Agents Chemother. 46(10):3215-22 Biochemical-genetic analysis and distribution of DES-1, an Ambler class A extended-spectrum beta-lactamase from Desulfovibrio desulfuricans. (PMID 12234847)

Resistomes

Prevalence of DES-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 600


>gb|AAM45855.1|+|DES-1 [Desulfovibrio desulfuricans]
MHSRSSYSRRYVLAGLCALPFASLSAGLIFNSSADAASLAAINGKTLQKKLAELEAASGGRLGVAARSSNGGKSLSYRGDERFPMCSTFK
VLAVAALLRDKPGILEQRIHFAQIDIQPWSPVTEKHLEDGMTVAELCAAMLQHSDNTAANLVLAKLGGPQGLTSLARSFGDTTFRLDRWE
VELNTAIPGDARDTTTPLAMCNTLNGLLCGNLLKAPARERLTGWMLGCATGAGRIPAGIPQGWRSAHKSGSGENGTANDVGVLLPPSNPG
KATKPGKNKGKPLTVALYLTGSRLTGPENDKILASATRLVCAAEGLAMPLDNMY


>gb|AF426161.1|+|119-1093|DES-1 [Desulfovibrio desulfuricans]
ATGCATTCCCGTTCCAGTTATTCCAGGCGCTATGTGCTCGCGGGCCTGTGCGCCCTGCCTTTTGCCTCGCTGAGCGCAGGCCTTATTTTC
AACAGCTCTGCTGATGCCGCCTCTCTTGCTGCAATTAACGGAAAAACCCTGCAAAAAAAGCTGGCCGAACTTGAGGCCGCAAGCGGCGGC
AGGCTTGGCGTGGCTGCCCGGTCAAGCAATGGCGGCAAAAGCCTGTCTTACCGTGGGGACGAACGCTTTCCCATGTGCAGCACCTTTAAA
GTGCTGGCAGTTGCGGCCCTTCTGCGGGACAAACCGGGCATTCTTGAACAGAGAATCCACTTTGCCCAAATCGACATCCAGCCCTGGTCG
CCCGTTACAGAAAAGCACCTTGAAGACGGCATGACTGTGGCAGAATTGTGCGCCGCCATGCTCCAGCACAGCGACAACACGGCTGCCAAC
CTTGTGCTTGCCAAACTGGGCGGCCCGCAAGGCCTGACCTCCCTTGCCCGCAGTTTTGGCGACACAACGTTTCGCCTTGACCGCTGGGAA
GTGGAACTGAATACGGCCATCCCCGGCGATGCGCGCGACACCACAACGCCCCTGGCCATGTGCAACACCCTGAACGGATTGCTGTGTGGC
AACCTGCTGAAAGCGCCCGCACGCGAACGACTGACAGGCTGGATGCTGGGCTGCGCAACCGGGGCCGGGCGCATCCCCGCAGGAATTCCG
CAGGGCTGGCGCTCTGCGCACAAAAGCGGCAGCGGAGAAAACGGCACCGCCAATGATGTAGGAGTATTGCTGCCGCCGAGCAACCCTGGC
AAAGCCACAAAGCCCGGCAAGAACAAAGGCAAGCCGCTGACTGTGGCCCTCTACCTCACGGGATCGCGACTGACCGGGCCGGAAAACGAC
AAAATCCTTGCCAGTGCAACCCGCCTGGTCTGCGCCGCAGAAGGGCTTGCGATGCCGCTCGACAATATGTATTGA