enmetazobactam [Adjuvant]

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Accession ARO:3007171
DefinitionEnmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis.
Classification5 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ beta-lactam derived beta-lactamase inhibitor
+ is_small_molecule_inhibitor OXA-10
+ is_small_molecule_inhibitor TEM-116
1 ontology terms | Show
+ cefepime-enmetazobactam [Antibiotic+Adjuvant] has_part

Lang PA, et al. 2022. Proc Natl Acad Sci U S A 119(18):e2117310119 Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. (PMID 35486701)

Bernhard F, et al. 2020. Antimicrob Agents Chemother 64(6): Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model. (PMID 32253212)