Accession | ARO:3007171 |
Definition | Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis. |
Classification | 5 ontology terms | Show |
Parent Term(s) | 3 ontology terms | Show + is_small_molecule_inhibitor TEM-116 + is_small_molecule_inhibitor OXA-10 + beta-lactam derived beta-lactamase inhibitor |
Sub-Term(s) | 1 ontology terms | Show + cefepime-enmetazobactam [Antibiotic+Adjuvant] has_part |
Publications | Lang PA, et al. 2022. Proc Natl Acad Sci U S A 119(18):e2117310119 Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. (PMID 35486701) Bernhard F, et al. 2020. Antimicrob Agents Chemother 64(6): Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model. (PMID 32253212) |