Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3007171 |
Definition | Enmetazobactam is a beta-lactamase inhibitor which exhibits activity against class A extended spectrum beta-lactamases. It is currently in clinical trials in combination with cefepine for the treatment of urinary tract infections and acute pyelonephritis. |
SMILES | C[n+]1ccn(C[C@@]2(C)[C@H](C(=O)[O-])N3C(=O)C[C@H]3S2(=O)=O)n1 |
PubChem | 23653540 |
ChEMBL | CHEMBL4458276 |
Classification | 5 ontology terms | Show |
Parent Term(s) | 3 ontology terms | Show + is_small_molecule_inhibitor_of TEM-116 + is_small_molecule_inhibitor_of OXA-10 + beta-lactam derived beta-lactamase inhibitor |
Sub-Term(s) | 1 ontology terms | Show + cefepime-enmetazobactam [Antibiotic+Adjuvant] has_part |
Publications | Lang PA, et al. 2022. Proc Natl Acad Sci U S A 119(18):e2117310119 Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. (PMID 35486701) Bernhard F, et al. 2020. Antimicrob Agents Chemother 64(6): Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model. (PMID 32253212) |
Curator | Description | Most Recent Edit |
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