allylamine antibiotic [Drug Class]

Accession ARO:3007498
DefinitionAllylamines are a group of antibiotics, particularly antifungals, that act as squalene epoxidase and ergosterol inhibitors. They have broad-spectrum activity against pathogenic fungi, especially dermatophytes. The two main allylamines are naftifine and terbinafine.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
3 ontology terms | Show
+ naftifine [Antibiotic]
+ terbinafine [Antibiotic]
+ Candida spp. pleiotropic drug resistance factor 1 confers_resistance_to_drug_class

Mühlbacher JM, et al. 1991. Clin Dermatol 9(4):479-85 Naftifine: a topical allylamine antifungal agent. (PMID 1822408)

Birnbaum JE, et al. 1990. J Am Acad Dermatol 23(4 Pt 2):782-5 Pharmacology of the allylamines. (PMID 2229523)