Candida spp. pleiotropic drug resistance factor 1

Accession ARO:3007640
DefinitionPDR1 is a transcription factor that regulates the expression of several genes encoding ABC transporters, contributing to multidrug resistance.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump, pleiotropic drug resistance transcription factors
Drug Classtriazole antibiotic, imidazole antibiotic, allylamine antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification15 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ regulates Candida spp. CDR1
+ regulates Candida spp. CDR2
+ pleiotropic drug resistance transcription factors [AMR Gene Family]
+ confers_resistance_to_drug_class allylamine antibiotic [Drug Class]
+ confers_resistance_to_drug_class triazole antibiotic [Drug Class]
+ confers_resistance_to_drug_class imidazole antibiotic [Drug Class]

Vermitsky JP, et al. 2004. Antimicrob Agents Chemother 48(10):3773-81 Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor. (PMID 15388433)