Candida spp. FKS2 with mutations conferring resistance to echinocandin antibiotics

Accession ARO:3007548
DefinitionGlucan synthase FKS2 is involved in the production of the fungal cell wall by the synthesis of the core component beta-1,3-glucan in Candida spp. Mutations in FKS2 have been shown to confer resistance to echinocandin antibiotic micafungin.
AMR Gene Familyechinocandin antibiotic-resistant beta-1,3-D-glucan synthase
Drug Classechinocandin antibiotic
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic micafungin [Antibiotic]
+ echinocandin antibiotic-resistant beta-1,3-D-glucan synthase [AMR Gene Family]
Publications

Garcia-Effron G, et al. 2009. Antimicrob Agents Chemother 53(9):3690-9 Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint. (PMID 19546367)

Curator Acknowledgements
Curator Description Most Recent Edit