| Accession | ARO:3007555 |
| Definition | Zn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics. |
| Drug Class | triazole antibiotic, imidazole antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + azole antibiotic + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 3 ontology terms | Show + mutant efflux regulatory protein conferring antibiotic resistance + confers_resistance_to_drug_class triazole antibiotic [Drug Class] + confers_resistance_to_drug_class imidazole antibiotic [Drug Class] |
| Sub-Term(s) | 1 ontology terms | Show |
| Publications | Coste A, et al. 2006. Genetics 172(4):2139-56 A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. (PMID 16452151) |