Zn2Cys6 transcription factors [AMR Gene Family]

Accession ARO:3007555
DefinitionZn2Cys6 is a transcription factor family that includes mutations to confer resistance to azole-class antibiotics.
Drug Classimidazole antibiotic, triazole antibiotic
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ mutant efflux regulatory protein conferring antibiotic resistance
+ confers_resistance_to_drug_class imidazole antibiotic [Drug Class]
+ confers_resistance_to_drug_class triazole antibiotic [Drug Class]
1 ontology terms | Show

Coste A, et al. 2006. Genetics 172(4):2139-56 A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. (PMID 16452151)