Candida spp. TAC1 with mutations conferring resistance to azole antibiotics

Accession ARO:3007563
DefinitionTAC1 is a Zn2Cys6 transcription factor that transcriptionally activates efflux units CDR1 and CDR2. Mutations in TAC1 upregulate CDR1 and CDR2 causing increased resistance.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump, Zn2Cys6 transcription factors
Drug Classimidazole antibiotic, triazole antibiotic, allylamine antibiotic
Resistance Mechanismantibiotic target alteration, antibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification18 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ Zn2Cys6 transcription factors [AMR Gene Family]
+ regulates Candida spp. CDR2
+ regulates Candida spp. CDR1

Coste A, et al. 2006. Genetics 172(4):2139-56 A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. (PMID 16452151)

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