| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009202 |
| CARD Short Name | Afum_CYP51a_ITZ |
| Definition | The P450 enzyme system, which may be alternatively named the Cyp51 enzyme system in some fungi, is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to the P450/Cyp51 genes have been shown to inhibit azole activity. |
| AMR Gene Family | azole-resistant fungal cytochrome P450 enzyme |
| Drug Class | azole antibiotic, benzimidazole antifungal, imidazole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + azole antibiotic [Drug Class] + antibiotic target + antibiotic resistance gene variant or mutant + benzimidazole antifungal [Drug Class] + fungal ergosterol synthesis pathway enzyme + antifungal-resistant cytochrome P450 enzyme + imidazole antibiotic [Drug Class] + triazole antifungal [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic itraconazole [Antibiotic] + azole-resistant fungal cytochrome P450 enzyme [AMR Gene Family] + derives_from antifungal susceptible Cyp51 enzyme |
| Publications | Diaz-Guerra TM, et al. 2003. Antimicrob Agents Chemother 47(3):1120-4 A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus. (PMID 12604551) Nascimento AM, et al. 2003. Antimicrob Agents Chemother 47(5):1719-26 Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole. (PMID 12709346) |
Private model - RGI is not currently using this model.
| Curator | Description | Most Recent Edit |
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