| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009412 |
| Synonym(s) | Nakaseomyces glabratus |
| Definition | Mutations in FKS2 are associated with modifications of the beta glucan in the fungal cell wall. As such, these mutations typically showcase increased resistance against echinocandin drugs. However, some studies have reported that some FKS2 mutations can result in increased resistance against azole drugs as well. |
| AMR Gene Family | azole resistant beta-1,3-glucan synthase |
| Drug Class | azole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + azole antibiotic [Drug Class] + antibiotic target + antibiotic resistance gene variant or mutant + antifungal resistant beta-1,3-glucan synthase + triazole antifungal [Drug Class] + cell wall synthesis enzyme targeted by antibiotic |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic fluconazole [Antibiotic] + derives_from antifungal-susceptible beta-1,3-glucan synthase + azole resistant beta-1,3-glucan synthase [AMR Gene Family] |
| Publications | Castanheira M, et al. 2014. Antimicrob Agents Chemother 58(1):577-80 Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates. (PMID 24126582) Alexander BD, et al. 2013. Clin Infect Dis 56(12):1724-32 Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. (PMID 23487382) Pham CD, et al. 2014. Antimicrob Agents Chemother 58(8):4690-6 Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance. (PMID 24890592) Healey KR, et al. 2016. Nat Commun 7:11128 Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. (PMID 27020939) Spettel K, et al. 2019. PLoS One 14(1):e0210397 Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing. (PMID 30629653) |
| Curator | Description | Most Recent Edit |
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