| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009422 |
| Synonym(s) | Nakaseomyces glabratus |
| Definition | Mutations in FKS2 are associated with modifications of the beta glucan in the fungal cell wall. As such, these mutations typically showcase increased resistance against echinocandin drugs. However, some studies have reported that some FKS2 mutations can result in increased resistance against azole drugs as well. |
| AMR Gene Family | azole resistant beta-1,3-glucan synthase |
| Drug Class | azole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + azole antibiotic [Drug Class] + antibiotic target + antibiotic resistance gene variant or mutant + antifungal resistant beta-1,3-glucan synthase + triazole antifungal [Drug Class] + cell wall synthesis enzyme targeted by antibiotic |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic fluconazole [Antibiotic] + derives_from antifungal-susceptible beta-1,3-glucan synthase + azole resistant beta-1,3-glucan synthase [AMR Gene Family] |
| Curator | Description | Most Recent Edit |
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