| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009559 |
| Definition | In Candida albicans, FKS1 encodes a catalytic subunit of the beta-1,3-D-glucan synthase complex typically associated with resistance to echinocandin antifungals. Although azoles primarily target ergosterol biosynthesis, rare FKS1 mutations have been reported to confer resistance. These mutations are thought to alter cell wall integrity and membrane to cell wall interactions, triggering compensatory stress response pathways that indirectly mitigate azole-mediated growth inhibition. Such cases represent uncommon, context-dependent resistance mechanisms rather than direct target-site resistance. |
| AMR Gene Family | azole resistant beta-1,3-glucan synthase |
| Drug Class | azole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + azole antibiotic [Drug Class] + antibiotic target + antibiotic resistance gene variant or mutant + antifungal resistant beta-1,3-glucan synthase + triazole antifungal [Drug Class] + cell wall synthesis enzyme targeted by antibiotic |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic fluconazole [Antibiotic] + derives_from antifungal-susceptible beta-1,3-glucan synthase + azole resistant beta-1,3-glucan synthase [AMR Gene Family] |
| Publications | Bédard C, et al. 2025. Nat Microbiol : FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance. (PMID 40790106) |
Private model - RGI is not currently using this model.
| Curator | Description | Most Recent Edit |
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