MexI

Accession ARO:3000808
DefinitionMexI is the inner membrane transporter of the efflux complex MexGHI-OpmD.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, phenicol antibiotic, glycylcycline, carbapenem, monobactam, acridine dye, fluoroquinolone antibiotic, triclosan, penam, diaminopyrimidine antibiotic, aminocoumarin antibiotic, antibacterial free fatty acids, macrolide antibiotic, aminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification26 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Schweizer HP. 2003. Genet Mol Res 2(1): 48-62. Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions. (PMID 12917802)

Aendekerk S, et al. 2005. Microbiology 151(PT 4): 1113-1125. The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. (PMID 15817779)

Resistomes

Prevalence of MexI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Citrobacter freundii0%0%0%
Enterobacter cloacae0%0%0%
Escherichia coli0%0%0%
Klebsiella pneumoniae0%0%0%
Proteus mirabilis0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Vibrio vulnificus0%0%0.68%
Show Perfect Only

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Citrobacter freundii0%0%0%
Enterobacter cloacae0%0%0%
Escherichia coli0%0%0%
Klebsiella pneumoniae0%0%0%
Proteus mirabilis0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Vibrio vulnificus0%0%0.68%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1900


>gb|NP_252896.1|+|mexI [Pseudomonas aeruginosa PAO1]
MTFTDLFVRRPVLALVVSTLILLLGLFSLGKLPIRQYPLLESSTITVTTEYPGASADLMQGFVTQPIAQAVSSVEGIDYLSSTSVQGRSV
VTIRMLLNRDSTQAMTETMAKVNSVRYKLPERAYDSVIERSSGETTAVAYVGFSSKTLPIPALTDYLSRVVEPMFSSIDGVAKVQTFGGQ
RLAMRLWLDADRLAGRGLTASDVAEAIRRNNYQAAPGMVKGQYVLSNVRVNTDLTNVDDFREMVIRNDGNGLVRLRDVGTVELGAAATET
SALMDGDPAVHLGLFPTPTGNPLVIVDGIRKLLPEIQKTLPPDVRVDLAYETSRFIQASIDEVVRTLVEALLIVVLVIYLCLGSLRSVLI
PVATIPLSMLGAAALMLAFGFSVNLLTLLAMVLAIGLVVDDAIVVVENVHRHIEEGKSPVAAALIGAREVAGPVIAMTITLAAVYTPIGL
MGGLTGALFREFALTLAGAVIVSGVVALTLSPVMSSLLLQAHQNEGRMGRAAEWFFGGLTRRYGQVLEFSLGHRWLTGGLALLVCISLPL
LYSMPKRELAPTEDQAAVLTAIKAPQHANLDYVELFARKLDQVYTSIPETVSTWIINGTDGPAASFGGINLAAWEKRERDASAIQSELQG
KVGDVEGSSIFAFQLAALPGSTGGLPVQMVLRSPQDYPVLYRTMEEIKQKARQSGLFVVVDSDLDYNNPVVQVRIDRAKANSLGIRMQDI
GESLAVLVGENYVNRFGMEGRSYDVIPQSLRDQRFTPQALARQFVRTQDGNLVPLSTVVRVALQVEPNKLIQFDQQNAATLQAIPAPGVS
MGQAVAFLDDVARGLPAGFSHDWQSDSRQYTQEGNTLVFAFLAALVVIYLVLAAQYESLADPLIILITVPLSICGALLPLALGYATMNIY
TQIGLVTLIGLISKHGILMVEFANELQLHERLDRRAAILRAAQIRLRPVLMTTAAMVFGLVPLLFASGAGAASRFGLGVVIVSGMLVGTL
FTLFVLPTVYTLLARNHAEVDKSPRSRQLAEADLLVNKA


>gb|NC_002516|+|4707535-4710624|mexI [Pseudomonas aeruginosa PAO1]
ATGACCTTTACCGACCTGTTCGTCCGCCGGCCGGTGCTGGCGCTGGTGGTCAGCACGCTGATCCTGCTGCTCGGCCTGTTCTCCCTGGGC
AAGCTGCCGATCCGCCAGTACCCGCTGCTGGAAAGCTCGACCATCACCGTCACCACCGAGTACCCCGGCGCCTCCGCCGATCTCATGCAA
GGCTTCGTCACCCAGCCGATCGCCCAGGCGGTGTCGTCGGTGGAGGGCATCGACTACCTTTCCTCGACCTCGGTGCAGGGGCGTAGCGTG
GTGACCATCCGCATGCTGCTCAACCGCGATTCGACCCAGGCGATGACCGAGACCATGGCCAAGGTCAACTCGGTGCGCTACAAGCTGCCC
GAGCGTGCCTACGACTCGGTGATCGAACGCTCTTCCGGCGAGACCACCGCGGTAGCCTACGTCGGCTTTTCCAGCAAGACCCTGCCGATC
CCGGCGTTGACCGACTACCTGTCGCGGGTGGTCGAGCCGATGTTCTCTTCCATCGACGGCGTGGCCAAGGTCCAGACCTTTGGCGGCCAG
CGCCTGGCCATGCGCCTCTGGCTCGACGCCGACCGCCTCGCCGGGCGCGGCCTGACCGCCTCCGACGTGGCCGAGGCGATCCGCCGCAAC
AACTACCAGGCGGCGCCGGGGATGGTGAAGGGGCAGTACGTGCTGTCCAACGTGCGGGTCAACACCGACCTGACCAACGTCGACGACTTC
CGCGAGATGGTCATCCGCAACGATGGCAACGGCCTGGTGCGCCTGCGCGACGTCGGTACCGTCGAACTGGGCGCCGCGGCCACCGAGACC
AGCGCACTGATGGACGGCGACCCGGCGGTGCACCTGGGGTTGTTCCCGACGCCCACCGGCAACCCGCTGGTGATCGTCGACGGCATCCGC
AAGCTGCTGCCGGAGATCCAGAAGACCCTGCCGCCGGATGTCCGCGTCGACCTCGCCTACGAGACTTCGCGCTTCATCCAGGCCTCCATC
GACGAGGTGGTGCGGACCCTGGTGGAAGCGCTGCTGATCGTGGTGCTGGTGATCTACCTCTGCCTCGGCTCGCTGCGCAGCGTGCTGATC
CCGGTGGCGACCATTCCCCTGTCGATGCTCGGCGCCGCCGCGCTGATGCTGGCCTTCGGCTTCAGCGTCAACCTGCTGACCCTGCTGGCG
ATGGTGCTGGCCATCGGGCTGGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCCACCGCCACATCGAGGAAGGCAAGTCGCCGGTG
GCGGCGGCGCTGATCGGCGCCCGCGAAGTGGCCGGCCCGGTGATCGCCATGACCATCACCCTGGCCGCCGTGTACACCCCCATCGGCCTG
ATGGGCGGCCTCACCGGCGCGCTGTTCCGCGAGTTCGCCCTGACCCTGGCGGGCGCGGTGATCGTGTCCGGGGTGGTGGCGCTGACCCTG
TCGCCGGTGATGAGTTCGCTGCTGCTCCAGGCGCACCAGAACGAGGGGCGCATGGGCCGCGCCGCCGAGTGGTTCTTCGGCGGCCTGACG
CGGCGCTACGGGCAGGTCCTGGAGTTCTCCCTGGGCCACCGCTGGCTGACCGGCGGCCTGGCATTGCTGGTGTGCATCAGCCTGCCGCTG
CTGTATTCGATGCCCAAGCGCGAACTGGCGCCGACCGAGGACCAGGCCGCGGTGCTCACCGCGATCAAGGCGCCGCAGCACGCCAACCTC
GACTATGTCGAACTGTTCGCGCGCAAGCTCGACCAGGTCTACACCAGCATCCCGGAAACCGTGAGCACCTGGATCATCAACGGCACCGAC
GGACCGGCGGCGAGCTTCGGCGGGATCAACCTGGCGGCCTGGGAAAAACGCGAGCGCGACGCCTCGGCGATCCAGTCCGAGCTGCAAGGC
AAGGTCGGCGATGTCGAGGGCAGCAGCATCTTCGCCTTCCAGTTGGCCGCCCTGCCCGGCTCCACCGGCGGCCTGCCGGTGCAGATGGTG
CTGCGCAGCCCGCAGGACTATCCAGTGCTCTACCGGACCATGGAAGAGATCAAGCAGAAGGCCCGACAGAGCGGGCTGTTCGTGGTGGTC
GACAGCGACCTCGACTACAACAACCCGGTGGTCCAGGTCCGCATCGACCGCGCCAAGGCCAACAGCCTGGGCATCCGCATGCAGGACATC
GGCGAGTCGCTGGCGGTGCTGGTGGGCGAGAACTACGTCAACCGCTTCGGCATGGAGGGCCGCTCCTACGACGTGATCCCACAGAGCCTG
CGCGACCAGCGTTTCACTCCGCAAGCGCTGGCACGACAGTTCGTGCGCACCCAGGACGGCAACCTGGTGCCGCTGTCGACGGTGGTCCGG
GTGGCGCTTCAGGTCGAACCGAACAAGCTGATCCAGTTCGACCAGCAGAACGCCGCGACCCTCCAGGCGATCCCCGCGCCCGGCGTCTCC
ATGGGCCAGGCGGTGGCCTTCCTCGACGACGTGGCGCGCGGCCTGCCGGCCGGCTTCAGCCACGACTGGCAATCCGACTCGCGGCAATAC
ACCCAGGAAGGCAACACCCTGGTGTTCGCCTTCCTCGCCGCCCTGGTGGTGATCTACCTGGTGCTCGCCGCGCAGTACGAGAGCCTGGCC
GACCCGCTGATCATCCTGATCACCGTGCCGCTGTCGATCTGCGGCGCGCTGCTGCCGCTGGCGCTGGGCTACGCGACGATGAACATCTAT
ACGCAGATCGGCCTGGTCACCCTGATCGGCCTGATCAGCAAGCACGGCATCCTCATGGTCGAGTTCGCCAACGAACTGCAACTCCACGAG
CGCCTCGACCGCCGCGCGGCGATCCTGCGCGCCGCGCAGATCCGCCTGCGGCCGGTGCTGATGACCACCGCGGCAATGGTCTTCGGCCTG
GTGCCGCTGCTCTTCGCCAGCGGCGCCGGCGCCGCCAGCCGCTTCGGCCTGGGCGTGGTGATCGTCTCCGGGATGCTGGTCGGCACCCTC
TTCACCCTGTTCGTGCTGCCCACCGTCTATACCCTGCTGGCGCGCAACCACGCGGAAGTCGACAAGAGCCCGCGCAGCCGGCAACTGGCC
GAGGCCGATCTGCTGGTGAACAAGGCATGA


Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1900


>gb|AAG07594.1|+|mexI [Pseudomonas aeruginosa PAO1]
MTFTDLFVRRPVLALVVSTLILLLGLFSLGKLPIRQYPLLESSTITVTTEYPGASADLMQGFVTQPIAQAVSSVEGIDYLSSTSVQGRSV
VTIRMLLNRDSTQAMTETMAKVNSVRYKLPERAYDSVIERSSGETTAVAYVGFSSKTLPIPALTDYLSRVVEPMFSSIDGVAKVQTFGGQ
RLAMRLWLDADRLAGRGLTASDVAEAIRRNNYQAAPGMVKGQYVLSNVRVNTDLTNVDDFREMVIRNDGNGLVRLRDVGTVELGAAATET
SALMDGDPAVHLGLFPTPTGNPLVIVDGIRKLLPEIQKTLPPDVRVDLAYETSRFIQASIDEVVRTLVEALLIVVLVIYLCLGSLRSVLI
PVATIPLSMLGAAALMLAFGFSVNLLTLLAMVLAIGLVVDDAIVVVENVHRHIEEGKSPVAAALIGAREVAGPVIAMTITLAAVYTPIGL
MGGLTGALFREFALTLAGAVIVSGVVALTLSPVMSSLLLQAHQNEGRMGRAAEWFFGGLTRRYGQVLEFSLGHRWLTGGLALLVCISLPL
LYSMPKRELAPTEDQAAVLTAIKAPQHANLDYVELFARKLDQVYTSIPETVSTWIINGTDGPAASFGGINLAAWEKRERDASAIQSELQG
KVGDVEGSSIFAFQLAALPGSTGGLPVQMVLRSPQDYPVLYRTMEEIKQKARQSGLFVVVDSDLDYNNPVVQVRIDRAKANSLGIRMQDI
GESLAVLVGENYVNRFGMEGRSYDVIPQSLRDQRFTPQALARQFVRTQDGNLVPLSTVVRVALQVEPNKLIQFDQQNAATLQAIPAPGVS
MGQAVAFLDDVARGLPAGFSHDWQSDSRQYTQEGNTLVFAFLAALVVIYLVLAAQYESLADPLIILITVPLSICGALLPLALGYATMNIY
TQIGLVTLIGLISKHGILMVEFANELQLHERLDRRAAILRAAQIRLRPVLMTTAAMVFGLVPLLFASGAGAASRFGLGVVIVSGMLVGTL
FTLFVLPTVYTLLARNHAEVDKSPRSRQLAEADLLVNKA


>gb|AE004091.2|+|4707535-4710624|mexI [Pseudomonas aeruginosa PAO1]
ATGACCTTTACCGACCTGTTCGTCCGCCGGCCGGTGCTGGCGCTGGTGGTCAGCACGCTGATCCTGCTGCTCGGCCTGTTCTCCCTGGGC
AAGCTGCCGATCCGCCAGTACCCGCTGCTGGAAAGCTCGACCATCACCGTCACCACCGAGTACCCCGGCGCCTCCGCCGATCTCATGCAA
GGCTTCGTCACCCAGCCGATCGCCCAGGCGGTGTCGTCGGTGGAGGGCATCGACTACCTTTCCTCGACCTCGGTGCAGGGGCGTAGCGTG
GTGACCATCCGCATGCTGCTCAACCGCGATTCGACCCAGGCGATGACCGAGACCATGGCCAAGGTCAACTCGGTGCGCTACAAGCTGCCC
GAGCGTGCCTACGACTCGGTGATCGAACGCTCTTCCGGCGAGACCACCGCGGTAGCCTACGTCGGCTTTTCCAGCAAGACCCTGCCGATC
CCGGCGTTGACCGACTACCTGTCGCGGGTGGTCGAGCCGATGTTCTCTTCCATCGACGGCGTGGCCAAGGTCCAGACCTTTGGCGGCCAG
CGCCTGGCCATGCGCCTCTGGCTCGACGCCGACCGCCTCGCCGGGCGCGGCCTGACCGCCTCCGACGTGGCCGAGGCGATCCGCCGCAAC
AACTACCAGGCGGCGCCGGGGATGGTGAAGGGGCAGTACGTGCTGTCCAACGTGCGGGTCAACACCGACCTGACCAACGTCGACGACTTC
CGCGAGATGGTCATCCGCAACGATGGCAACGGCCTGGTGCGCCTGCGCGACGTCGGTACCGTCGAACTGGGCGCCGCGGCCACCGAGACC
AGCGCACTGATGGACGGCGACCCGGCGGTGCACCTGGGGTTGTTCCCGACGCCCACCGGCAACCCGCTGGTGATCGTCGACGGCATCCGC
AAGCTGCTGCCGGAGATCCAGAAGACCCTGCCGCCGGATGTCCGCGTCGACCTCGCCTACGAGACTTCGCGCTTCATCCAGGCCTCCATC
GACGAGGTGGTGCGGACCCTGGTGGAAGCGCTGCTGATCGTGGTGCTGGTGATCTACCTCTGCCTCGGCTCGCTGCGCAGCGTGCTGATC
CCGGTGGCGACCATTCCCCTGTCGATGCTCGGCGCCGCCGCGCTGATGCTGGCCTTCGGCTTCAGCGTCAACCTGCTGACCCTGCTGGCG
ATGGTGCTGGCCATCGGGCTGGTGGTGGACGACGCCATCGTGGTGGTGGAGAACGTCCACCGCCACATCGAGGAAGGCAAGTCGCCGGTG
GCGGCGGCGCTGATCGGCGCCCGCGAAGTGGCCGGCCCGGTGATCGCCATGACCATCACCCTGGCCGCCGTGTACACCCCCATCGGCCTG
ATGGGCGGCCTCACCGGCGCGCTGTTCCGCGAGTTCGCCCTGACCCTGGCGGGCGCGGTGATCGTGTCCGGGGTGGTGGCGCTGACCCTG
TCGCCGGTGATGAGTTCGCTGCTGCTCCAGGCGCACCAGAACGAGGGGCGCATGGGCCGCGCCGCCGAGTGGTTCTTCGGCGGCCTGACG
CGGCGCTACGGGCAGGTCCTGGAGTTCTCCCTGGGCCACCGCTGGCTGACCGGCGGCCTGGCATTGCTGGTGTGCATCAGCCTGCCGCTG
CTGTATTCGATGCCCAAGCGCGAACTGGCGCCGACCGAGGACCAGGCCGCGGTGCTCACCGCGATCAAGGCGCCGCAGCACGCCAACCTC
GACTATGTCGAACTGTTCGCGCGCAAGCTCGACCAGGTCTACACCAGCATCCCGGAAACCGTGAGCACCTGGATCATCAACGGCACCGAC
GGACCGGCGGCGAGCTTCGGCGGGATCAACCTGGCGGCCTGGGAAAAACGCGAGCGCGACGCCTCGGCGATCCAGTCCGAGCTGCAAGGC
AAGGTCGGCGATGTCGAGGGCAGCAGCATCTTCGCCTTCCAGTTGGCCGCCCTGCCCGGCTCCACCGGCGGCCTGCCGGTGCAGATGGTG
CTGCGCAGCCCGCAGGACTATCCAGTGCTCTACCGGACCATGGAAGAGATCAAGCAGAAGGCCCGACAGAGCGGGCTGTTCGTGGTGGTC
GACAGCGACCTCGACTACAACAACCCGGTGGTCCAGGTCCGCATCGACCGCGCCAAGGCCAACAGCCTGGGCATCCGCATGCAGGACATC
GGCGAGTCGCTGGCGGTGCTGGTGGGCGAGAACTACGTCAACCGCTTCGGCATGGAGGGCCGCTCCTACGACGTGATCCCACAGAGCCTG
CGCGACCAGCGTTTCACTCCGCAAGCGCTGGCACGACAGTTCGTGCGCACCCAGGACGGCAACCTGGTGCCGCTGTCGACGGTGGTCCGG
GTGGCGCTTCAGGTCGAACCGAACAAGCTGATCCAGTTCGACCAGCAGAACGCCGCGACCCTCCAGGCGATCCCCGCGCCCGGCGTCTCC
ATGGGCCAGGCGGTGGCCTTCCTCGACGACGTGGCGCGCGGCCTGCCGGCCGGCTTCAGCCACGACTGGCAATCCGACTCGCGGCAATAC
ACCCAGGAAGGCAACACCCTGGTGTTCGCCTTCCTCGCCGCCCTGGTGGTGATCTACCTGGTGCTCGCCGCGCAGTACGAGAGCCTGGCC
GACCCGCTGATCATCCTGATCACCGTGCCGCTGTCGATCTGCGGCGCGCTGCTGCCGCTGGCGCTGGGCTACGCGACGATGAACATCTAT
ACGCAGATCGGCCTGGTCACCCTGATCGGCCTGATCAGCAAGCACGGCATCCTCATGGTCGAGTTCGCCAACGAACTGCAACTCCACGAG
CGCCTCGACCGCCGCGCGGCGATCCTGCGCGCCGCGCAGATCCGCCTGCGGCCGGTGCTGATGACCACCGCGGCAATGGTCTTCGGCCTG
GTGCCGCTGCTCTTCGCCAGCGGCGCCGGCGCCGCCAGCCGCTTCGGCCTGGGCGTGGTGATCGTCTCCGGGATGCTGGTCGGCACCCTC
TTCACCCTGTTCGTGCTGCCCACCGTCTATACCCTGCTGGCGCGCAACCACGCGGAAGTCGACAAGAGCCCGCGCAGCCGGCAACTGGCC
GAGGCCGATCTGCTGGTGAACAAGGCATGA