streptothricin acetyltransferase (SAT) [AMR Gene Family]

Accession ARO:3000869
DefinitionAcetylCoA dependent acetyltransferase that acetylate streptothricins such as nourseothricin at position 16 (beta position of beta-lysine).
Drug Classnucleoside antibiotic
Resistance Mechanismantibiotic inactivation
Classification5 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ antibiotic inactivation enzyme
+ participates_in acylation of antibiotic conferring resistance
+ confers_resistance_to_drug_class nucleoside antibiotic [Drug Class]
5 ontology terms | Show
+ SAT-2
+ SAT-4
+ SAT-3
+ sta
+ SatA

Zahringer U, et al. 1993. FEMS Microbiol Lett 110(3): 331-334. Nourseothricin (streptothricin) inactivated by a plasmid pIE636 encoded acetyl transferase of Escherichia coli: location of the acetyl group. (PMID 8394835)

Kobayashi T, et al. 1987. J Antibiot (Tokyo) 40(7): 1016-1022. Purification and biochemical characterization of streptothricin acetyltransferase coded by the cloned streptothricin-resistance gene of Streptomyces lavendulae. (PMID 3624064)