CFE-1

Accession ARO:3001856
CARD Short NameCFE-1
DefinitionCFE-1 is a beta-lactamase found in Escherichia coli.
AMR Gene FamilyCMY beta-lactamase
Drug Classcephamycin
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsCitrobacter freundiig+wgs
Classification16 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ CMY beta-lactamase [AMR Gene Family]
Publications

Nakano R, et al. 2004. Antimicrob Agents Chemother 48(4): 1151-1158. CFE-1, a novel plasmid-encoded AmpC beta-lactamase with an ampR gene originating from Citrobacter freundii. (PMID 15047515)

Resistomes

Prevalence of CFE-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter freundii4.1%0%0.58%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 700


>gb|BAC76072.1|+|CFE-1 [Escherichia coli]
MMKKSICCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAIIYQGKPYYFTWGKADIANNRPVTQQTLFELGSVSKTFN
GVLGGDAIARGEIKLSDPVTQYWPELTGKQWQGISLLHLATYTAGGLPLQVPDDVTDKAALLRFYQNWQPQWAPGAKRLYANSSIGLFGA
LAVKPSGMSYEEAMTTRVLQPLKLAHTWITVPQSEQKDYALGYREGKPVHVSPGQLDAEAYGVKSSVVDMTRWVQANMDASQVQEKTLQQ
GIKLAQSRYWRIGDMYQGLGWEMLNWPVKADSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLA
NKSYPNPARVEAAWRILEKLQ


>gb|AB107899.1|+|1008-2153|CFE-1 [Escherichia coli]
ATGATGAAAAAATCGATATGCTGCGCGCTGCTGCTGACAGCCTCTTTTTCCACCTTTGCCGCCGCAAAAACAGAACAACAAATTGCCGAT
ATCGTTAACCGCACCATCACACCGCTGATGCAGGAGCAGGCTATTCCGGGTATGGCCGTTGCGATTATCTACCAGGGAAAACCTTATTAC
TTTACCTGGGGTAAAGCTGATATCGCCAATAACCGTCCAGTCACTCAGCAAACGCTGTTTGAACTCGGCTCGGTCAGTAAAACGTTCAAC
GGCGTGCTGGGCGGCGATGCTATCGCTCGCGGCGAAATCAAGCTCAGCGATCCGGTCACGCAATACTGGCCTGAGCTGACGGGTAAGCAG
TGGCAGGGTATCAGCCTGCTGCACTTAGCGACCTACACGGCAGGCGGCCTGCCGCTTCAGGTTCCCGACGACGTCACGGATAAAGCCGCC
TTACTGCGTTTTTATCAAAACTGGCAGCCACAATGGGCACCGGGCGCTAAACGTCTTTACGCTAACTCCAGCATTGGTCTGTTTGGCGCA
CTGGCGGTGAAACCTTCAGGCATGAGCTACGAAGAGGCGATGACCACCCGCGTCCTGCAGCCCTTAAAACTGGCGCATACATGGATTACG
GTTCCACAGAGCGAACAAAAAGATTATGCATTGGGCTATCGCGAAGGAAAGCCTGTGCATGTATCCCCTGGCCAACTTGATGCCGAAGCC
TATGGGGTAAAATCAAGCGTTGTCGATATGACCCGCTGGGTCCAGGCCAACATGGATGCCAGCCAGGTTCAGGAGAAAACGCTCCAGCAG
GGAATCAAGCTTGCGCAGTCACGTTACTGGCGTATTGGCGATATGTACCAGGGTCTGGGCTGGGAGATGCTGAACTGGCCGGTGAAAGCC
GACTCAATAATTAACGGTAGCGACAGCAAAGTGGCGCTGGCAGCGCTTCCCGCCGTTGAGGTAAACCCGCCCGCGCCTGCTGTGAAAGCA
TCATGGGTGCATAAAACGGGCTCCACTGGCGGATTCGGCAGCTACGTTGCTTTCGTTCCAGAAAAAAACCTTGGCATTGTGATGCTGGCA
AACAAGAGCTATCCAAACCCTGCTCGCGTCGAGGCCGCCTGGCGCATTCTTGAAAAACTGCAGTAA