| Accession | ARO:3002120 |
| CARD Short Name | CMY-108 |
| Definition | CMY-108 is a beta-lactamase present in plasmids of clinical Escherichia coli from humans and companion animals in the upper Midwestern USA . Name originally from the historical Lahey list of beta-lactamases, some of which did not include sequence data. |
| AMR Gene Family | CMY beta-lactamase |
| Drug Class | cephalosporin |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter portucalensiswgs |
| Resistomes with Sequence Variants | Citrobacter portucalensiswgs |
| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase + antibiotic molecule + class C beta-lactamase + beta-lactam antibiotic + CMY-LAT-MOX beta-lactamase + cephalosporin [Drug Class] + second-generation cephalosporin + CMY-MOX beta-lactamase + CMY-LAT beta-lactamase |
| Parent Term(s) | 1 ontology terms | Show + CMY beta-lactamase [AMR Gene Family] |
| Publications | Bortolaia V, et al. 2014. J Antimicrob Chemother 69(6): 1492-1496. High diversity of plasmids harbouring blaCMY-2 among clinical Escherichia coli isolates from humans and companion animals in the upper Midwestern USA. (PMID 24500191) |
Prevalence of CMY-108 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Citrobacter portucalensis | 0% | 0% | 3.6% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700
| Curator | Description | Most Recent Edit |
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