LRA-1

Accession ARO:3002482
CARD Short NameLRA-1
DefinitionLRA-1 is a beta-lactamase isolated from soil samples in Alaska.
AMR Gene Familyclass A LRA beta-lactamase
Drug Classcephalosporin, penam
Resistance Mechanismantibiotic inactivation
Classification14 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ class A LRA beta-lactamase [AMR Gene Family]
Publications

Allen HK, et al. 2009. ISME J 3(2): 243-251. Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil. (PMID 18843302)

Resistomes

Prevalence of LRA-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 525


>gb|ACH58980.1|-|LRA-1 [uncultured bacterium BLR1]
MNPPIHRRTLLLAASVLPLASACTAWSAKGPQQDASAQLAALEAASGSRLGVVGFNTATGARVQHRAEERFPFCSTFKLMLAAAVLERSA
KEGDLLARRVNYSKGDLVSYSPITEKNVATGMTVAELCAATVQYSDNGAANLLMKILGGPSAVTAFARASGDEVFRLDRWETELNTAIPG
DLRDTTTPAAMAASVQRLVLGNALGAAQREQLKTWLLGNTTSTQRFLAGVPAGWKVGDKTGSGSYGTTNDVGVLWPPAGAPLVLAVYLTF
PQKEAKGRSDVVASATRIAVSALAS


>gb|EU408346.1|-|4826-5713|LRA-1 [uncultured bacterium BLR1]
ATGAATCCTCCAATCCATCGCCGCACCCTGTTGCTCGCCGCCTCGGTCCTCCCGCTCGCAAGCGCCTGCACCGCGTGGTCCGCCAAGGGG
CCGCAGCAAGACGCATCGGCGCAGCTCGCCGCGCTCGAAGCCGCATCGGGCAGCCGGCTCGGTGTGGTCGGTTTCAACACCGCCACCGGC
GCGCGCGTGCAGCACCGTGCCGAGGAACGCTTTCCGTTCTGCAGCACCTTCAAGCTCATGCTGGCCGCGGCCGTCCTCGAACGCAGCGCG
AAAGAGGGCGACCTGCTCGCGCGCCGCGTCAACTACAGCAAGGGCGACCTGGTCTCCTACTCGCCCATCACCGAAAAGAATGTGGCGACC
GGCATGACGGTGGCCGAGCTGTGCGCCGCCACCGTCCAGTACAGCGACAACGGCGCGGCCAACCTGCTGATGAAGATCCTGGGCGGCCCG
TCCGCCGTGACGGCCTTTGCGCGTGCCTCCGGCGACGAGGTCTTCAGGCTGGACCGCTGGGAGACCGAACTCAACACCGCCATCCCCGGC
GACCTGCGCGACACCACCACGCCCGCGGCCATGGCGGCAAGCGTGCAGCGGCTGGTGCTGGGCAACGCGCTGGGCGCGGCACAGCGCGAG
CAGCTCAAGACCTGGTTGCTGGGCAACACCACGAGCACCCAGCGCTTCCTGGCCGGCGTGCCCGCCGGCTGGAAGGTGGGCGACAAGACC
GGTTCGGGCTCCTACGGCACCACGAACGACGTGGGCGTGCTGTGGCCGCCGGCCGGCGCGCCGCTGGTGCTGGCGGTCTACCTGACGTTT
CCGCAGAAGGAGGCGAAGGGGCGCAGCGATGTGGTTGCGTCGGCGACGCGCATTGCGGTGAGCGCGCTGGCGAGCTGA