carA

Accession ARO:3002817
DefinitioncarA is an ABC-F subfamily protein involved in macrolide resistance. It is found in Streptomyces thermotolerans
AMR Gene FamilyABC-F ATP-binding cassette ribosomal protection protein
Drug Classphenicol antibiotic, streptogramin antibiotic, lincosamide antibiotic, tetracycline antibiotic, pleuromutilin antibiotic, macrolide antibiotic, oxazolidinone antibiotic
Resistance Mechanismantibiotic target protection
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family]
Publications

Schoner B, et al. 1992. Gene 115(1-2): 93-96. Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins. (PMID 1612454)

Resistomes

Prevalence of carA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1050


>gb|AAC32027.1|+|carA [Streptomyces thermotolerans]
MSTAQLALHDITKRYQDHVVLDRIGFTIKPGEKVGVIGDNGSGKSTLIKLIAGREQPDNGAVTVVAPGGVGYLAQTLELPLEATVQDAVD
LALADLRELEEGMRRTEAELAERPYQTGQDPELAGLLESYAALVDRYQARGGYEADSRVEIALHGLGLPGLERGRRLGTLSGGERSRLAL
AATLASEPELLLLDEPTNDLDDRAVDWLEEHLRKHKGTVVAVTHDRLFLDRLTTTILEIDSGKVMRYGNGYEGYLAAKAAERQRRLLEYE
QWRAELDRSRDLIASNVARLDAIPRKLPFAVFGAGQFRMRGRGHGAMVRIRNAKERVARLTENPVAPPPEPLTFTAEITTEAAQSRETVA
ELTGVRVGDRLSVDSLHLGPGERLLVTGPNGAGKTTLLRVLSGELEPDSGSLLVSGRVGHLRQEQTPWRPGMTVLQAFSSGRAGDIDEHT
EALLSLGLFSPDDLRQRVQDLSYGQRRRIELARLVTEPVDLLLLDEPTNHLSPALVEELEEALTGYQGTVVVVTHDRRMRSRFNGAHLTL
QDGRVAEFTAA


>gb|M80346|+|1-1656|carA [Streptomyces thermotolerans]
GTGTCGACAGCGCAACTAGCTCTGCATGACATCACCAAGCGTTACCAGGACCACGTCGTACTCGACCGGATCGGCTTCACCATCAAGCCG
GGCGAGAAGGTCGGTGTCATCGGGGACAACGGATCCGGCAAGTCCACGCTGATCAAGCTCATCGCCGGGCGGGAACAGCCGGACAACGGT
GCGGTGACGGTGGTCGCGCCCGGTGGCGTCGGCTATCTGGCCCAGACACTGGAGCTGCCGCTGGAGGCCACGGTCCAGGACGCCGTCGAT
CTGGCCCTGGCCGACCTGCGGGAGCTGGAGGAGGGCATGCGCCGGACCGAGGCCGAGCTGGCCGAACGGCCCTACCAAACGGGCCAAGAC
CCCGAACTCGCCGGCCTCCTGGAGAGTTACGCCGCGCTGGTGGACCGGTATCAGGCCCGCGGCGGCTACGAGGCCGACTCCCGCGTGGAG
ATCGCGCTGCACGGGCTCGGGCTGCCCGGGCTGGAACGCGGCCGGCGGCTGGGCACCCTGTCCGGCGGCGAGCGCTCGCGCCTCGCCCTG
GCGGCGACGCTGGCCTCGGAACCCGAACTGCTGCTGTTGGACGAGCCGACCAACGACCTGGACGACCGGGCCGTGGACTGGCTGGAGGAA
CACCTGCGCAAGCACAAAGGCACCGTTGTCGCCGTTACCCACGACCGGCTCTTCCTCGACCGGCTCACCACCACGATCCTGGAGATCGAC
TCCGGCAAGGTGATGCGCTACGGCAACGGCTACGAGGGCTACCTGGCAGCCAAGGCGGCGGAACGGCAGCGCAGGCTGCTTGAGTACGAG
CAGTGGCGCGCCGAGCTGGACCGCAGCCGCGACCTGATCGCGTCCAACGTGGCGCGTCTGGACGCCATCCCACGCAAGCTGCCCTTCGCC
GTCTTCGGCGCCGGCCAGTTCCGGATGCGCGGGCGGGGCCATGGTGCGATGGTGCGGATCCGCAACGCCAAGGAACGCGTCGCGCGGCTG
ACCGAAAACCCGGTCGCGCCGCCGCCCGAGCCGCTCACCTTCACCGCGGAGATCACCACCGAGGCCGCGCAGTCCCGGGAGACGGTGGCC
GAACTCACCGGCGTCCGGGTCGGCGACCGGCTCAGCGTCGACTCCCTGCACCTCGGGCCCGGTGAACGGCTGCTGGTCACCGGCCCCAAC
GGGGCGGGCAAGACGACGCTGCTGCGGGTGCTCTCCGGGGAGCTGGAACCCGACAGCGGATCCCTGCTGGTGTCGGGCCGGGTGGGACAC
CTGAGGCAGGAACAGACACCATGGCGGCCGGGTATGACGGTGCTTCAGGCGTTCAGCAGCGGACGGGCCGGTGACATCGACGAGCACACC
GAGGCGCTGCTCTCCCTCGGGCTGTTCAGCCCGGACGACCTCCGCCAGCGTGTGCAGGACCTGTCGTACGGGCAGCGGCGCCGCATCGAG
CTTGCCCGGCTGGTGACGGAGCCGGTCGACCTGCTGCTGCTGGACGAACCCACCAACCACCTCTCGCCCGCGCTCGTCGAGGAACTGGAG
GAGGCGCTGACCGGTTATCAGGGCACGGTCGTCGTCGTCACCCACGACCGGCGCATGCGGTCCCGCTTCAACGGCGCCCATCTGACGCTG
CAGGACGGGCGCGTCGCCGAGTTCACCGCCGCCTGA