oleB

Accession ARO:3003036
CARD Short NameoleB
DefinitionoleB is an ABC-F subfamily protein in Streptomyces antibioticus and is involved in oleandomycin secretion.
AMR Gene FamilyMiscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic target protection
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic oleandomycin [Antibiotic]
+ Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins [AMR Gene Family]
Publications

Buche A, et al. 1997. Biochem J 321(PT 1): 139-144. Interaction between ATP, oleandomycin and the OleB ATP-binding cassette transporter of Streptomyces antibioticus involved in oleandomycin secretion. (PMID 9003412)

Resistomes

Prevalence of oleB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1100


>gb|AAA50325.1|+|oleB [Streptomyces antibioticus]
MQNAHRSDTGAAALTGTPEKLLPTQPETGSFQVVLDDVVRAPGGRPLLDGVNQSVALGERVGIIGENGSGKSTLLRMLAGVDRPDGGQVL
VRAPGGCGYLPQTPDLPPEDTVQDAIDHALAELRSLERGLREAEQALAGAEPEELEGLLGAYGDLLEAFEARDGYAADARVDAAMHGLGL
AGITGDRRLGSLSGGEQARLNLACLLAASPQLMLLDEPTNHLDVGALEWLEERLRAHRGSVLVVSHDRVFLERVATALWEVDGERRTVNR
HGGGYAGYLQAKAAARRRWEQAYQDWLEDLARQRELARSAADHLATGPRRNTERSNQRHQRNVEKQISARVRNAKERVRRLEENPVPRPP
QPMRFRARVEGGGTVGRGGALAELYKVTVGTRLDVPSFTVDPGERILITGHNGAGKSTLLRVLAGDLAPDQGECERPERIGWLPQETEIT
DRQQSLLAAFAAGLPGIAEEHRGALLGFGLFRPSALGTAVGDLSTGQLRRLALARLLRDPADLLLLDEPTNHLSPALVEDLEEALAHYRG
ALVVVSHDRMFAQRFTGRRMHMEGGRFVE


>gb|L36601.1|+|1421-3130|oleB [Streptomyces antibioticus]
ATGCAGAACGCACACCGTTCCGATACCGGCGCCGCGGCGCTCACCGGCACGCCGGAAAAGCTCCTTCCCACGCAACCTGAGACCGGTTCC
TTCCAGGTCGTCCTCGACGACGTCGTCCGGGCACCCGGCGGACGGCCGCTGTTGGACGGCGTCAACCAGTCGGTGGCACTCGGCGAGCGC
GTCGGCATCATCGGTGAGAACGGATCGGGCAAGTCGACCCTGCTCCGCATGCTCGCCGGCGTGGACCGCCCGGACGGTGGCCAGGTCCTC
GTCCGGGCTCCCGGCGGCTGCGGCTACCTCCCCCAGACACCGGACCTGCCCCCGGAGGACACCGTTCAGGACGCCATCGACCACGCCCTC
GCCGAACTGCGCTCCCTGGAGCGGGGGTTGCGTGAGGCGGAGCAGGCGCTGGCCGGGGCGGAGCCCGAGGAGCTGGAGGGCCTGCTCGGC
GCCTACGGCGACCTGCTGGAGGCGTTCGAGGCCCGCGACGGCTACGCGGCGGACGCCCGTGTCGACGCGGCGATGCACGGCCTCGGTCTG
GCGGGCATCACGGGCGACCGGCGGCTCGGCAGCCTCTCCGGAGGTGAGCAGGCGCGTCTCAACCTGGCCTGCCTGCTGGCCGCGTCCCCG
CAGCTGATGCTGCTCGACGAACCCACCAACCACCTCGACGTCGGGGCGCTGGAGTGGCTGGAGGAGCGCCTGCGGGCCCACCGCGGCAGC
GTGCTGGTCGTCTCGCACGACCGGGTCTTCCTGGAGCGCGTGGCCACCGCCCTGTGGGAGGTGGACGGCGAGCGGCGCACCGTCAACCGG
CACGGCGGCGGTTACGCGGGATACCTGCAAGCCAAGGCGGCCGCGCGGCGCCGCTGGGAGCAGGCTTACCAGGACTGGCTGGAGGACCTG
GCACGCCAGCGGGAACTGGCCCGCAGCGCCGCCGACCACCTGGCCACCGGCCCGCGGCGCAACACCGAGCGGTCGAACCAGCGCCACCAG
CGCAACGTGGAGAAGCAGATCTCCGCGCGGGTCCGCAACGCCAAGGAGCGGGTCCGCCGGCTGGAGGAGAACCCGGTGCCGCGGCCCCCT
CAACCCATGCGTTTCCGGGCCCGGGTGGAGGGTGGCGGCACGGTCGGGCGCGGCGGGGCACTCGCCGAGCTGTACAAGGTCACCGTCGGC
ACGCGGCTCGACGTCCCGTCCTTCACCGTCGACCCCGGTGAGCGCATCCTGATCACGGGGCACAACGGCGCGGGCAAGAGCACCCTGCTG
CGCGTGCTGGCCGGTGACCTGGCGCCCGATCAGGGCGAGTGCGAGCGCCCGGAGCGCATCGGCTGGCTGCCGCAGGAGACGGAGATCACC
GACCGGCAGCAGAGCCTGCTGGCGGCCTTCGCGGCGGGGCTGCCCGGCATCGCGGAGGAACACCGGGGCGCGCTCCTGGGATTCGGGCTC
TTCCGGCCCTCGGCGCTGGGCACCGCGGTGGGAGACCTGTCCACCGGGCAGTTGAGGCGGCTGGCCCTGGCCCGTCTGCTGCGCGACCCG
GCGGACCTGCTGCTGCTCGACGAGCCGACGAACCACCTGTCGCCCGCGCTCGTGGAGGACCTGGAGGAGGCGCTGGCGCACTACCGGGGC
GCACTGGTCGTGGTCTCCCACGACCGCATGTTCGCGCAGCGGTTCACCGGTCGCCGCATGCACATGGAGGGTGGCCGCTTCGTGGAGTGA