opcM

Accession ARO:3003037
DefinitionOpcM is an outer membrane factor protein found in Burkholderia cepacia. It is part of the CeoAB-OpcM complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic, antibacterial free fatty acids, monobactam, penam, triclosan, diaminopyrimidine antibiotic, phenicol antibiotic, macrolide antibiotic, carbapenem, aminocoumarin antibiotic, glycylcycline, acridine dye, aminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification23 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Burns JL, et al. 1996. Antimicrob Agents Chemother 40(2): 307-313. Nucleotide sequence analysis of a gene from Burkholderia (Pseudomonas) cepacia encoding an outer membrane lipoprotein involved in multiple antibiotic resistance. (PMID 8834871)

Resistomes

Prevalence of opcM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Burkholderia cenocepacia0%0%2.91%
Burkholderia cepacia0%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 980


>gb|AAC43969.1|+|opcM [Burkholderia cepacia]
MDNMHNTNGLMRFAKVAAASTLLATLLAACAVGPDYQRPDAVVPAAFKEAPTLAAGEQAGTWKTAEPSDGRTPRRMVKVFGDPVLDSLET
QALAANQNLKAAAARVEEARAATRSARSQWFPQVGAGFGPTREGLSSASQFQPQGTGPTNATLWRAQGTVSYEADLFGRVGRNVEASRAD
QAQSEALFRSVQLALQADVAQNYFELRQLDSDQDLYHRTVELREQALKLVQRRFNEGDISELDVSRAKNELASAQADAVDVARRRAASEH
ALAILLGKAPADFAFKETPIVPVAVKIPPGLPSALLERRPDVSAAERAMAAANARIGLAKSAYFRSSISPGRSAISVDARQPVPVVEPYF
LLGPFAGTALTLPLFDGGRRAAGVQQARAQYDEQGANYRQQVLVAFREVEDNLADLRLLDDQIRAQEAAVNASRRAATLSRSEYQEGEVA
YLDVIDSERSVLQSQLQANQLTGAQAVSTVNLIRALGGGWGNAPAPTAVGDAASGKADVAAR


>gb|U38944.1|+|1-1536|opcM [Burkholderia cepacia]
ATGGACAACATGCACAACACGAACGGCCTGATGCGCTTCGCGAAGGTGGCGGCCGCGAGCACCCTGCTCGCGACGCTGCTCGCCGCGTGT
GCGGTCGGCCCCGACTACCAGCGTCCCGACGCGGTGGTGCCCGCCGCGTTCAAGGAAGCGCCGACCCTCGCCGCCGGCGAGCAGGCCGGC
ACGTGGAAGACGGCCGAGCCGTCGGATGGCCGAACACCGCGGCGAATGGTGAAGGTGTTCGGCGACCCGGTGCTCGATTCGCTCGAGACG
CAGGCGCTTGCCGCGAACCAGAACCTGAAGGCCGCGGCCGCGCGGGTCGAGGAAGCGCGGGCGGCGACGCGTTCGGCGCGCTCGCAATGG
TTCCCGCAGGTCGGCGCCGGTTTCGGGCCGACGCGCGAGGGGCTGTCGTCGGCGTCGCAGTTCCAGCCGCAGGGCACCGGCCCGACCAAC
GCGACGCTGTGGCGCGCGCAGGGCACGGTGTCGTACGAAGCCGATCTGTTCGGCCGCGTCGGCCGCAACGTCGAGGCGTCGCGTGCCGAT
CAGGCGCAGAGCGAAGCGCTGTTCCGTTCGGTGCAGCTCGCGCTGCAGGCCGACGTCGCGCAGAACTACTTCGAACTGCGTCAGCTCGAT
TCGGACCAGGACCTGTACCACCGCACGGTCGAGTTGCGCGAGCAGGCACTGAAGCTCGTGCAGCGCCGCTTCAACGAAGGCGACATCAGC
GAGCTCGACGTGTCGCGCGCGAAGAACGAACTGGCGAGCGCGCAGGCCGATGCGGTCGACGTCGCGCGCCGGCGCGCGGCGTCCGAGCAT
GCGCTCGCCATCCTGCTCGGCAAGGCGCCCGCGGATTTCGCGTTCAAGGAAACGCCGATCGTGCCGGTCGCGGTGAAGATTCCGCCGGGC
CTGCCGTCCGCGCTGCTCGAACGCCGCCCGGACGTGTCGGCGGCCGAACGCGCGATGGCGGCCGCGAACGCGCGGATCGGGCTCGCGAAG
TCGGCGTACTTCCGAAGCTCGATATCACCGGGTCGTTCGGCTATAAGCGTCGACGCTCGGCAACCTGTTCCTGTGGTCGAGCCGTACTTC
CTGCTCGGGCCGTTCGCCGGTACCGCGCTGACGTTGCCGCTGTTCGACGGCGGACGGCGGGCGGCCGGCGTGCAGCAGGCGCGCGCGCAG
TACGACGAGCAGGGCGCGAACTACCGGCAGCAGGTGCTCGTCGCGTTCCGCGAGGTCGAGGACAATCTCGCCGATCTGCGTTTGCTCGAT
GATCAGATCCGCGCGCAGGAGGCGGCCGTCAATGCGTCGCGCCGGGCGGCGACGTTGTCGCGCAGCGAATATCAGGAAGGCGAGGTCGCA
TATCTCGACGTGATCGACAGCGAGCGCTCGGTGCTGCAGTCGCAGTTGCAGGCGAACCAGTTGACGGGTGCGCAGGCGGTGTCGACCGTC
AATCTGATCCGTGCGCTGGGCGGCGGGTGGGGGAATGCGCCGGCGCCGACGGCGGTGGGTGATGCGGCGTCTGGCAAGGCTGACGTAGCT
GCGCGG