mexN

Accession ARO:3003705
DefinitionMexN is the inner membrane transporter of the MexMN-OprM multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Mima T, et al. 2009. Microbiology (Reading, Engl.) 155(Pt 11):3509-17 Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa. (PMID 19713238)

Resistomes

Prevalence of mexN among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Citrobacter koseri0%0%0%
Enterobacter cloacae0%0%0%
Escherichia coli0%0%0%
Klebsiella oxytoca0%0%0%
Klebsiella pneumoniae0%0%0%
Proteus mirabilis0%0%0%
Pseudomonas aeruginosa0%0%0%
Pseudomonas fluorescens3.7%0%0%
Serratia marcescens0%0%0%
Staphylococcus aureus0%0%0.01%
Vibrio vulnificus0%0%0.68%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1900


>gb|BAE06006.1|+|mexN [Pseudomonas aeruginosa]
MTPRAGISGWCVRHPIATALLTLASLLLGLLAFLRLGVAPLPEADFPTIQINALLPGGSPETMASSVATPLEVQFSAIPGITEMTSSSAL
GTTTLTLQFSLDKSIDVAAQEVQAAINAAAGRLPVDMPNLPTWRKVNPADSPIMILRVNSEMMPLIELSDYAETILARQLSQVNGVGQIF
VVGQQRPAIRIQAQPEKLAAYQLTLADLRQSLQSASVNLAKGALYGEGRVSTLAANDQLFNASDYDDLVVAYRQGAPVFLKDVARIVSAP
EDDYVQAWPNGVPGVALVILRQPGANIVDTADAIQAALPRLREMLPATIEVDVLNDRTRTIRSSLHEVELTLLLTIGLVVLVMGLFLRQL
SATLIVATVLAVSLSASFAAMYVLGFTLNNLTLVALIIAVGFIVDDAIVVVENIHRHLEAGASKVEAALKGAAEIGFTVISISFSLIAAF
IPLLFMGGIVGRLFREFAVSVTVAILISVVASLTLAPMLASRFMPALRHAEAPRKGFAEWLTGGYERGLRWALGHQRLMLVGFAFTVLVA
VAGYVGIPKGFFPLQDTAFVIGTSQAAEDISYDDMVAKHRQLAEIIASDPAVQSYNHAVGVTGGSQSLANGRFWIVLKDRGERDVSVGEF
IDRLRPQLAKVPGIMLYLRAAQDINLSSGPSRTQYQYALRSSDSTQLALWAQRLTERLKQVPGLMDVSNDLQVGASVTALDIDRVAAARF
GLSAEDVSQTLYDAFGQRQVGEYQTEVNQYKVVLELDARQRGRAESLDWFYLRSPLSGEMVPLSAIAKVAAPRSGPLQINHNGMFPAVNL
SFNLAAGVSLGEAVQAVQRAQEEIGMPSTIIGVFQGAAQAFQSSLASQPLLILAALIAVYIILGVLYESFVHPLTILSTLPSAGIGAVFL
LWAWGQDFSIMALIGIVLLIGIVKKNGILMVDFAIVAQREQGMSAEQAIYQACLTRFRPIMMTTLAALLGAIPLMIGFGTGSELRQPLGI
AVVGGLLVSQVLTLFSTPVVYLALERLFHRRGTTTSDGGTAGATAT


>gb|AB219523.1|+|1176-4286|mexN [Pseudomonas aeruginosa]
GTGACGCCGCGCGCCGGGATTTCCGGCTGGTGCGTACGGCACCCGATCGCCACCGCGCTGCTGACCCTGGCCTCGCTGCTGCTGGGGCTG
CTGGCGTTCCTCCGGCTCGGTGTGGCGCCGTTGCCGGAGGCGGACTTCCCGACCATCCAGATCAACGCCTTGCTGCCCGGCGGTAGCCCG
GAGACCATGGCCTCGTCGGTGGCCACCCCCTTGGAAGTGCAGTTCAGCGCGATTCCCGGGATCACCGAGATGACTTCCAGCAGCGCCCTG
GGCACCACCACCCTGACCCTGCAGTTCAGCCTCGACAAGAGCATCGACGTCGCCGCCCAGGAGGTCCAGGCGGCGATCAACGCCGCGGCC
GGGCGGCTGCCGGTGGACATGCCGAACCTGCCGACCTGGCGCAAGGTCAACCCGGCGGACAGCCCGATCATGATCCTGCGGGTCAACTCG
GAGATGATGCCGCTGATCGAACTCAGCGATTACGCCGAGACCATCCTCGCCCGCCAGCTCAGCCAGGTGAACGGCGTGGGGCAGATCTTC
GTGGTCGGCCAGCAGCGCCCGGCGATCCGCATCCAGGCCCAGCCGGAGAAGCTCGCCGCCTACCAGCTGACCCTGGCCGACCTGCGCCAG
TCGTTGCAGTCGGCCAGCGTCAACCTGGCCAAGGGCGCGCTCTACGGCGAGGGGCGGGTGTCGACCCTCGCGGCCAACGACCAGTTGTTC
AACGCCAGCGACTATGACGACCTGGTGGTCGCCTACCGCCAGGGCGCGCCGGTGTTCCTCAAGGACGTGGCGCGGATCGTCTCGGCGCCC
GAGGACGACTACGTGCAGGCCTGGCCGAACGGCGTGCCCGGGGTGGCGCTGGTGATCCTGCGCCAGCCTGGGGCGAACATCGTCGATACC
GCCGACGCGATCCAGGCCGCGCTGCCACGCCTGCGCGAGATGCTCCCGGCGACCATCGAGGTAGACGTGCTCAACGACCGCACCCGGACC
ATCCGCTCGTCGTTGCACGAGGTCGAACTGACCCTGCTGCTGACCATTGGCCTGGTGGTGCTGGTGATGGGCCTGTTCCTCCGCCAGCTG
TCGGCGACCCTGATCGTCGCCACGGTGCTGGCGGTGTCCCTGAGCGCCAGCTTCGCGGCGATGTACGTGCTCGGCTTCACCCTCAACAAC
CTGACCCTGGTGGCGCTGATCATCGCTGTCGGCTTCATCGTCGACGACGCCATCGTGGTCGTGGAGAACATCCACCGACACCTGGAAGCG
GGCGCCTCGAAGGTCGAGGCGGCGCTCAAGGGCGCGGCGGAGATCGGCTTTACCGTGATTTCCATCAGCTTCTCGCTGATCGCCGCGTTC
ATTCCCCTGCTGTTCATGGGCGGGATCGTCGGCCGGCTGTTCCGCGAATTCGCGGTCAGCGTGACGGTGGCGATCCTGATCTCGGTGGTC
GCTTCGCTGACCCTGGCGCCGATGCTGGCTTCGCGCTTCATGCCGGCATTGCGGCATGCCGAAGCGCCGAGAAAGGGCTTCGCCGAATGG
CTGACCGGCGGCTACGAACGCGGCCTGCGCTGGGCGCTCGGGCACCAGCGGCTGATGCTGGTCGGCTTCGCCTTTACCGTGCTGGTGGCG
GTGGCCGGCTACGTCGGGATTCCCAAGGGTTTCTTCCCCTTGCAGGACACCGCCTTCGTCATCGGCACGAGCCAGGCTGCCGAGGATATC
TCCTACGACGACATGGTCGCCAAGCACCGGCAACTGGCCGAGATCATCGCCAGCGACCCGGCGGTGCAGAGCTACAACCATGCGGTGGGC
GTCACCGGCGGTAGCCAGAGCCTGGCCAACGGACGTTTCTGGATCGTCCTCAAGGACCGTGGCGAGCGCGATGTCTCGGTCGGCGAGTTC
ATCGACCGGCTGCGCCCGCAACTGGCCAAGGTGCCGGGAATCATGCTCTACCTGCGCGCGGCGCAGGACATCAACCTCAGTTCCGGACCC
TCGCGGACCCAGTACCAGTACGCCCTGCGCAGCAGCGACAGCACCCAGCTGGCGCTCTGGGCGCAACGCCTCACCGAGCGCCTGAAGCAG
GTGCCGGGGCTGATGGATGTGTCCAACGACCTGCAGGTCGGCGCCAGCGTCACCGCGCTGGACATCGACCGGGTGGCCGCGGCGCGTTTC
GGCCTCAGCGCCGAGGATGTCAGCCAGACCCTCTACGACGCCTTCGGCCAGCGCCAGGTCGGCGAGTACCAGACCGAGGTCAACCAGTAC
AAGGTGGTCCTCGAACTCGATGCGCGCCAGCGCGGCCGCGCGGAAAGCCTGGACTGGTTCTACCTGCGCTCGCCGCTGAGCGGCGAGATG
GTCCCGCTGTCGGCCATCGCCAAGGTCGCGGCGCCGCGCTCCGGGCCGCTGCAGATCAACCACAACGGCATGTTCCCGGCGGTCAACCTG
TCCTTCAACCTGGCTGCCGGGGTGTCCCTCGGCGAGGCGGTGCAGGCGGTGCAGCGCGCCCAGGAGGAGATCGGCATGCCCTCGACCATT
ATCGGCGTGTTCCAGGGCGCGGCGCAGGCCTTCCAGAGCTCGCTGGCCTCGCAACCGCTGCTGATCCTCGCCGCGCTGATCGCGGTGTAC
ATCATCCTCGGCGTGCTCTACGAGAGTTTCGTACATCCGCTGACGATCCTCTCGACCCTGCCCTCGGCGGGGATCGGCGCGGTGTTCCTG
CTCTGGGCCTGGGGCCAGGACTTCTCGATCATGGCGCTGATCGGCATCGTGCTGCTGATCGGCATCGTCAAGAAGAACGGCATCCTCATG
GTCGACTTCGCCATCGTCGCCCAGCGCGAGCAGGGCATGAGCGCGGAGCAGGCGATCTACCAGGCCTGCCTGACCCGTTTCCGGCCGATC
ATGATGACCACCCTGGCCGCGCTGCTGGGCGCGATACCCCTGATGATCGGCTTCGGCACCGGTTCCGAGCTGCGCCAGCCTCTGGGCATC
GCGGTGGTCGGCGGGCTGCTGGTGAGCCAGGTGCTGACCCTGTTCAGCACGCCGGTGGTATACCTGGCCCTGGAGCGGCTGTTCCACCGG
CGCGGGACGACGACCTCGGACGGCGGAACCGCTGGGGCGACGGCGACATGA