moxalactam [Antibiotic]

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Accession ARO:3004017
DefinitionMoxalactam (Latamoxef) is a broad spectrum cephalosporin (oxacephem) and beta-lactam antibiotic. Moxalactam binding to PBPs inhibits peptidoglycan cross-linkage in the cell wall, resulting in cell death. Moxalactam is proposed to be effective against meningitides as it passes the blood-brain barrier.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
3 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ Serratia marcescens Omp1 confers_resistance_to_antibiotic
+ ACC-1 confers_resistance_to_antibiotic

Fu KP, et al. 1979. J. Antibiot. 32(9):909-14 The comparative beta-lactamase resistance and inhibitory activity of 1-oxa cephalosporin, cefoxitin and cefotaxime. (PMID 315938)

Webber JA, et al. . Rev. Infect. Dis. 4 Suppl:S496-500 Moxalactam: the first of a new class of beta-lactam antibiotics. (PMID 6218558)