Accession | ARO:3004193 |
Definition | Sed beta-lactamases are Class A beta-lactamases that are capable of hydrolyzing benzypenicillin, cephalothin, and cloxacillin. |
Drug Class | cephalosporin, penam |
Resistance Mechanism | antibiotic inactivation |
Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + beta-lactam antibiotic + cephem + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactamase |
Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_drug_class penam [Drug Class] + class A beta-lactamase |
Sub-Term(s) | 1 ontology terms | Show + Sed-1 |
Publications | Rogers MB, et al. 1994. J Bacteriol 176(14): 4376-4384. Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates. (PMID 7517394) |