BUT-1

Accession ARO:3004294
CARD Short NameBUT-1
DefinitionA chromosome-encoded class C cephalosporinase and penicillinase from Buttiauxella spp. shown clinically to confer resistance to beta-lactam antibiotics. Described by Fihman et al. 2002.
AMR Gene FamilyBUT beta-lactamase
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ BUT beta-lactamase [AMR Gene Family]
Publications

Fihman V, et al. 2002. FEMS Microbiol. Lett. 213(1):103-11 BUT-1: a new member in the chromosomal inducible class C beta-lactamases family from a clinical isolate of Buttiauxella sp. (PMID 12127496)

Resistomes

Prevalence of BUT-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AAN17791.1|+|BUT-1 [Buttiauxella agrestis]
MCRTLCHVTYGRFSMMKKTLCCALVLSASFSAFAAQKTLSDKQLEEAVNQTLKPMITAQAIPGMAVAVIYQGKPHYFTYGVADIAKNQPV
TTQTIFELGSVSKTFTGVLGGDIVARGEVKLSDPAMKYWPELTGKQWQGITLLDLATYTAGGLPLQVPDEVDNQAALLKFYQNWQPDWAP
GTRRQYANSSIGLFGALAVKPSGMTFNDAMRQRVLQPLNLKHTWLTVPASEENHYAWGYRDGKAMHVGPGMLDTEAYGVKSTIEDMASWV
QYNMNPQQVKQPTLQKGLEIAQSRYWRSGSMYQGLGWEMLNWPVAAATVINGSDNKVALAASPVTAIEPPVAPVKASLVHKTGSTNGFGA
YVAFIPEKQIGIVMLANKMYPNTERVKAANTLLNTLQ


>gb|AF440406.1|+|960-2153|BUT-1 [Buttiauxella agrestis]
ATGTGCCGGACCCTCTGTCATGTTACTTATGGAAGATTTTCAATGATGAAAAAAACACTCTGCTGCGCGCTGGTTCTGAGCGCCTCTTTC
TCCGCCTTTGCTGCACAAAAAACATTGAGTGACAAACAGTTAGAAGAGGCTGTCAATCAAACGCTTAAACCGATGATTACAGCCCAGGCC
ATTCCCGGCATGGCGGTGGCGGTGATTTATCAGGGCAAGCCGCACTACTTTACCTACGGCGTGGCCGACATCGCGAAAAATCAGCCGGTG
ACGACACAGACGATTTTTGAGCTGGGCTCCGTGAGTAAAACTTTCACCGGCGTGCTGGGCGGCGATATCGTGGCGCGCGGGGAAGTGAAG
CTGAGTGACCCGGCGATGAAATACTGGCCAGAACTGACGGGCAAGCAGTGGCAGGGCATCACGTTGCTGGATCTGGCGACCTACACCGCC
GGCGGCTTGCCGTTGCAGGTGCCGGATGAGGTCGATAATCAGGCCGCGCTGCTGAAGTTTTACCAGAACTGGCAGCCGGACTGGGCGCCG
GGAACCCGTCGTCAGTACGCCAACTCGAGCATTGGCCTGTTTGGTGCGTTGGCAGTGAAACCGTCCGGGATGACGTTTAACGATGCGATG
CGCCAGCGCGTTCTGCAACCGCTGAACCTGAAACATACCTGGCTCACCGTTCCGGCCAGTGAAGAAAATCATTACGCCTGGGGCTATCGT
GACGGCAAAGCCATGCACGTCGGGCCGGGCATGCTGGATACCGAAGCCTACGGTGTCAAATCCACCATCGAAGATATGGCGAGCTGGGTG
CAATACAACATGAACCCGCAGCAGGTGAAACAGCCGACGCTGCAAAAAGGGCTGGAGATTGCGCAGTCGCGCTACTGGCGCAGCGGCAGT
ATGTATCAGGGCTTAGGCTGGGAAATGCTGAACTGGCCGGTTGCGGCGGCGACCGTCATTAACGGCAGCGATAACAAAGTGGCGCTGGCG
GCTTCGCCCGTGACGGCCATTGAACCGCCGGTTGCGCCGGTGAAAGCTTCTCTGGTGCATAAAACCGGGTCGACCAACGGCTTCGGCGCG
TACGTGGCGTTCATTCCTGAAAAACAAATCGGCATCGTGATGCTGGCTAACAAAATGTATCCGAATACCGAGCGGGTTAAAGCGGCAAAT
ACTCTTCTCAACACGCTGCAATAA

Curator Acknowledgements
Curator Description Most Recent Edit