| Accession | ARO:3004456 |
| CARD Short Name | Efac_ACT_CHL |
| Definition | A chloramphenicol resistance determinant described in an Enterococcus faecium plasmid. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Brevibacillus laterosporuswgs, Enterococcus faecaliswgs, Enterococcus faeciump+wgs, Staphylococcus arlettaewgs, Staphylococcus aureusg+p+wgs, Staphylococcus epidermidiswgs, Staphylococcus haemolyticuswgs, Staphylococcus saprophyticuswgs |
| Resistomes with Sequence Variants | Brevibacillus laterosporuswgs, Enterococcus faecaliswgs, Enterococcus faeciump+wgs, Staphylococcus arlettaewgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitiswgs, Staphylococcus epidermidiswgs, Staphylococcus equorumwgs, Staphylococcus haemolyticuswgs, Staphylococcus saprophyticuswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance |
| Parent Term(s) | 2 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] |
| Publications | Grady R, et al. 2003. Mol Microbiol 47(5): 1419-1432. Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. (PMID 12603745) |
Prevalence of Enterococcus faecium chloramphenicol acetyltransferase among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Brevibacillus laterosporus | 0% | 0% | 2.94% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.49% | 0% |
| Enterococcus faecium | 0% | 0.19% | 0.48% | 0% |
| Staphylococcus arlettae | 0% | 0% | 7.5% | 0% |
| Staphylococcus aureus | 0.61% | 0.04% | 0.52% | 0% |
| Staphylococcus capitis | 0% | 0% | 0.63% | 0% |
| Staphylococcus epidermidis | 0% | 0% | 0.33% | 0% |
| Staphylococcus equorum | 0% | 0% | 1.79% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.88% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 2.1% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 350