serine-rich repeat glycoproteins

Accession VIRO:0000466
Synonym(s)SRR
DefinitionSerine-rich repeat (SRR) glyoproteins characterized by two heavily glycosylated serine-rich regions (SRRs), one or two species-unique nonrepeat regions [NR domains, which include the binding region (BR) domain] toward the N terminus that facilitate specific interactions with a diverse array of host receptors and share little sequence homology to each other, and a C-terminal cell wall anchor domain.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ adhesin [Virulence Factor]
Sub-Term(s)
14 ontology terms | Show
Publications

Pyburn TM, et al. 2011. PLoS Pathog. 7(7):e1002112 A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. (PMID 21765814)

Yakovenko O, et al. 2018. Infect. Immun. 86(6): Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets. (PMID 29581195)