emtA

Accession ARO:3004669
CARD Short NameemtA
DefinitionA rRNA methyltransferase conferring high-level evernimicin resistance.
AMR Gene Familynon-erm 23S ribosomal RNA methyltransferase (G748)
Drug Classorthosomycin antibiotic, lincosamide antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsEnterococcus faeciumg+p+wgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ non-erm 23S ribosomal RNA methyltransferase (G748) [AMR Gene Family]
+ confers_resistance_to_antibiotic evernimicin [Antibiotic]
Publications

Mann PA, et al. 2001. Mol Microbiol 41(6): 1349-1356. EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance. (PMID 11580839)

Resistomes

Prevalence of emtA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Enterococcus faecium0.32%0.13%0.2%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 600


>gb|AAL02176.1|+|emtA [Enterococcus faecium]
MTLYFASVLSGLEYVLSNEINNKVSDSEIIQINRGKVFFTTAESFTCLSSLRSADHLFQVIDQFQIGPHKKHLSQVSERISQLDLEFIDH
KDLFWVNASRKGKQTYSRFELAKKAMEGINKRYPDWNIGTSQNHQIEFRLDIEHHNVIFSLRLTDATFRFRNQTRRFSRASLLPSVAHAM
VWLSDPESKDVFVDFCCGSGTILSERATYPANQIIGGDISEAVTKIAKSNLDDSKVQVNVWDARKLPFSTGCVDKIVTNLPFGRQISPDE
DLELFNHHIMIEVCRVLKPNGRAVILSESVNQLFWEAKRLGLFCLESYPLSLKGVNPTLFVFEKQDGLRRK


>gb|AF403298.1|+|660-1685|emtA [Enterococcus faecium]
ATGACTCTTTATTTTGCGAGCGTATTGTCTGGATTAGAATACGTTTTATCAAATGAAATTAACAACAAGGTGAGTGATTCTGAAATAATT
CAAATAAATAGAGGGAAGGTTTTCTTTACCACAGCTGAGTCTTTTACATGCTTAAGTTCTTTAAGGTCAGCAGATCACTTGTTTCAAGTT
ATTGATCAATTTCAAATCGGTCCACATAAAAAGCACTTATCTCAGGTAAGCGAGCGAATATCCCAGTTGGATTTAGAATTTATTGATCAT
AAAGATTTATTTTGGGTAAATGCAAGCCGTAAAGGAAAACAAACCTATAGTCGCTTTGAATTAGCAAAAAAAGCAATGGAGGGTATTAAT
AAGCGTTACCCTGATTGGAACATTGGAACGTCTCAAAATCATCAGATAGAATTCAGACTCGACATTGAACATCATAATGTGATTTTTTCA
CTTCGGCTTACAGATGCGACGTTTCGTTTTCGAAATCAGACACGACGGTTCTCTCGTGCATCATTACTTCCTTCTGTGGCTCATGCGATG
GTGTGGTTGTCAGATCCTGAATCGAAAGATGTTTTCGTAGACTTTTGTTGTGGTTCAGGCACAATTTTGTCTGAACGAGCCACATACCCT
GCAAATCAGATAATTGGTGGAGATATATCTGAAGCAGTCACAAAGATAGCCAAAAGTAATCTCGATGATTCGAAGGTGCAAGTTAATGTT
TGGGATGCACGGAAATTGCCTTTTTCTACTGGCTGTGTCGATAAAATTGTTACTAATCTTCCATTTGGAAGACAAATTTCCCCTGACGAG
GACTTAGAATTGTTCAATCACCATATTATGATTGAAGTATGTAGAGTCTTGAAGCCAAATGGGAGAGCCGTTATTTTGTCTGAGAGTGTC
AATCAATTGTTTTGGGAAGCAAAACGATTAGGCCTTTTTTGTCTGGAATCTTATCCTTTGAGTTTGAAGGGCGTGAATCCTACCTTGTTT
GTGTTTGAAAAACAAGATGGACTTAGAAGGAAGTAG