| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3004833 |
| Synonym(s) | ponA |
| CARD Short Name | Ngon_PBP1_BLA |
| Definition | Point mutation in Neisseria gonorrhoea PBP1 (ponA) decreases affinity between beta-lactam antibiotic molecule and PBP1, thereby conferring resistance to beta-lactam antibiotics. |
| AMR Gene Family | Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics |
| Drug Class | penicillin beta-lactam, cephalosporin, carbapenem, monobactam |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Neisseria gonorrhoeaeg+p+wgs |
| Classification | 72 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + penicillin beta-lactam [Drug Class] + cephalosporin [Drug Class] + beta-lactamase resistant penicillin + beta-lactamase sensitive penicillin + penicillin with extended spectrum + other cephalosporins and penems + fourth-generation cephalosporin + third-generation cephalosporin + second-generation cephalosporin + first-generation cephalosporin + antibiotic target + mechanism of antibiotic resistance + carbapenem [Drug Class] + monobactam [Drug Class] + moxalactam [Antibiotic] + loracarbef [Antibiotic] + cefradine [Antibiotic] + cephapirin [Antibiotic] + ceftizoxime [Antibiotic] + ceftiofur [Antibiotic] + cefprozil [Antibiotic] + cefonicid [Antibiotic] + cefmetazole [Antibiotic] + mecillinam [Antibiotic] + cell wall synthesis enzyme targeted by antibiotic + cefalotin [Antibiotic] + ceftaroline [Antibiotic] + cefdinir [Antibiotic] + cefditoren [Antibiotic] + ceftibuten [Antibiotic] + cefpodoxime [Antibiotic] + cefixime [Antibiotic] + cefotaxime [Antibiotic] + cefaclor [Antibiotic] + cefotiam [Antibiotic] + cefadroxil [Antibiotic] + cefalexin [Antibiotic] + doripenem [Antibiotic] + mezlocillin [Antibiotic] + azlocillin [Antibiotic] + ampicillin [Antibiotic] + flucloxacillin [Antibiotic] + dicloxacillin [Antibiotic] + propicillin [Antibiotic] + phenoxymethylpenicillin [Antibiotic] + benzylpenicillin [Antibiotic] + aztreonam [Antibiotic] + imipenem [Antibiotic] + antibiotic target alteration [Resistance Mechanism] + piperacillin [Antibiotic] + meropenem [Antibiotic] + ertapenem [Antibiotic] + amoxicillin [Antibiotic] + cefuroxime [Antibiotic] + ceftriaxone [Antibiotic] + ceftobiprole [Antibiotic] + ceftazidime [Antibiotic] + cefepime [Antibiotic] + cefazolin [Antibiotic] + oxacillin [Antibiotic] + carbenicillin [Antibiotic] + methicillin [Antibiotic] + cloxacillin [Antibiotic] + cefoxitin [Antibiotic] + beta-lactam sensitive penicillin-binding protein + mutation conferring antibiotic resistance + determinant of antibiotic resistance + beta-lactam resistant penicillin-binding proteins + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 1 ontology terms | Show |
| Publications | Ropp PA, et al. 2002. Antimicrob. Agents Chemother. 46(3):769-77 Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. (PMID 11850260) |
Prevalence of Neisseria gonorrhoeae PBP1 conferring resistance to beta-lactam antibiotics among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Neisseria gonorrhoeae | 51.25% | 0.51% | 58.33% | 0% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 1475
PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).| Mutation | Mutation type | PubMed |
|---|---|---|
| L421P | single resistance variant | PMID:11850260 |
| Curator | Description | Most Recent Edit |
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