CMH-2

Accession ARO:3006854
CARD Short NameCMH-2
DefinitionCMH-2 is a CMH beta-lactamase.
AMR Gene FamilyCMH beta-lactamase
Drug Classcephalosporin
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsEnterobacter cloacaeg+wgs
Classification13 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ CMH beta-lactamase [AMR Gene Family]
Resistomes

Prevalence of CMH-2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Enterobacter cloacae1.79%0%1.6%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 750


>gb|WP_063859588.1|+|CMH-2 [Klebsiella pneumoniae]
MMTKSLSCALLLSVACSAFAAPMSEKQLADVVERTVTPLMKAQAIPGMAVAVIYQGQPHYFTFGKADVAANKPVTPQTLFELGSVSKTFT
GVLGGDAIARKEISLADPVTKYWPELTGKQWQGIRLLDLATYTAGGLPLQVPDAVTDNASLLRFYQSWQPKWAPGTTRLYANTSIGLFGS
LAVKPSGMRFEEAMTERVFKPLKLNHTWINVPHAEESHYAWGYREGKAVHVSPGMLDAEAYGVKSNVKDMASWVMANMAPETLPQSTLQQ
GIALAQSRYWRVGAMYQGLGWEMLNWPVDAKTVVDGSDNKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLA
NKSYPNPVRVETAYRILDALQ


>gb|NG_048767.1|+|1-1146|CMH-2 [Klebsiella pneumoniae]
ATGATGACAAAATCCCTAAGCTGCGCGCTGCTGCTCAGCGTTGCCTGCTCTGCTTTTGCCGCGCCGATGTCAGAAAAACAGCTGGCTGAC
GTCGTGGAACGTACCGTTACGCCTCTGATGAAGGCGCAGGCCATACCCGGAATGGCCGTGGCCGTCATTTATCAGGGCCAGCCACACTAT
TTTACTTTCGGTAAAGCAGACGTTGCGGCGAATAAGCCCGTCACGCCGCAAACCTTATTTGAGCTGGGCTCCGTCAGCAAAACCTTCACC
GGCGTGCTGGGTGGCGATGCCATTGCCCGCAAAGAGATTTCGCTGGCCGACCCGGTCACAAAATATTGGCCTGAATTGACGGGCAAGCAG
TGGCAAGGCATTCGCCTGCTAGACCTGGCAACCTATACCGCAGGTGGATTGCCGTTGCAGGTGCCGGATGCTGTCACCGATAACGCCTCT
CTGCTGCGTTTCTACCAGTCCTGGCAGCCAAAGTGGGCCCCGGGTACTACGCGTCTGTACGCCAACACCAGCATCGGTTTGTTTGGCTCA
CTGGCGGTTAAACCTTCCGGCATGCGCTTTGAGGAGGCCATGACGGAGCGGGTCTTTAAGCCCCTGAAACTCAACCATACGTGGATAAAC
GTTCCACACGCTGAAGAGTCGCACTACGCATGGGGTTATCGTGAGGGAAAAGCGGTCCACGTTTCGCCTGGTATGCTGGATGCAGAAGCC
TATGGCGTGAAATCTAACGTCAAAGATATGGCGAGCTGGGTGATGGCCAATATGGCACCTGAGACACTCCCGCAGTCCACTCTGCAGCAG
GGTATTGCGCTGGCGCAGTCTCGCTACTGGCGCGTGGGTGCCATGTATCAAGGGTTAGGCTGGGAGATGCTCAACTGGCCGGTCGACGCC
AAAACCGTGGTGGATGGCAGCGATAATAAGGTCGCACTGGCGCCGTTGCCGGTCGCAGAAGTGAATCCTCCGGCTCCGCCAGTAAAAGCC
TCCTGGGTGCATAAAACGGGCTCTACGGGTGGGTTTGGCAGCTACGTGGCGTTTATTCCTGAAAAGCAGATCGGTATTGTGATGCTCGCA
AATAAAAGCTATCCGAACCCGGTACGGGTGGAAACGGCTTACCGTATCCTCGACGCGCTACAGTAA