carbenicillin [Antibiotic]

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Accession ARO:0000043
Synonym(s)Microcillin Pyopen Carbecin Carbenicillina Carbenicilina CAR Geopen Carbenicilline Anabactyl Carbenicillinum
DefinitionCarbenicillin is a semi-synthetic antibiotic belonging to the carboxypenicillin subgroup of the penicillins. It has gram-negative coverage which includes Pseudomonas aeruginosa but limited gram-positive coverage. The carboxypenicillins are susceptible to degradation by beta-lactamase enzymes. Carbenicillin antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.
Drug Classpenam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penam [Drug Class]
Sub-Term(s)
2 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ Acinetobacter baumannii AbuO confers_resistance_to_antibiotic
Publications

Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804)

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)

Butler K, et al. 1970. J Infect Dis 122(SUPPL:S1-SUPPL): S8. Carbenicillin: chemistry and mode of action. (PMID 4248289)