blaR1

Accession ARO:3000217
CARD Short NameblaR1
DefinitionblaR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the blaZ/blaR1/blaI operon.
AMR Gene FamilyBlaZ beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification16 ontology terms | Show
Parent Term(s)3 ontology terms | Show
Resistomes

Prevalence of blaR1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1150


>gb|ABU39979.1|-|blaR1 [Alkalihalobacillus clausii]
MTLPHILLSLVLITATILVIFFVRAVFYKQLSAKWRYHLWFLLITVLTLPFIPIHLLTGLSFFDQGRQQITPSAQKRFGFADQNEQWMVD
FGTSVSRFDDTFIHAVFVSIWIGGMIFFLLLTLYHYAKLQRLVKAASRIQNQKVENAFSDCMAELQITNKLTNLESPAIQTPMTFGWLKT
YILLPKNIELYLSDDEIRHVLLHELHHYKSKHIKVNYIFVVYQIVYWFHPLVWKAFKEMRLDRELACDTEVLLTLGQREYKAYGQTIMRF
LERNSRFLYLTNPLHSSKKAFKNTKSYNIAFFYWRVKSGAQLKKPWVVFAGLTRFCIAQFPFLTATAVSTERYQFDESQAVVEDYSTYFA
GNEGSFVLYSLTSDQFEIYNKEKSVRRVSPNSSYKIYTALMALELGVIGRDDSWLEWDGVEYEDEAWNSGQDLKSAMSQSVTWYFQELDE
RIKQRNIQSFVNQLDYGNKDLSGGLNHYWLESSLKISPVEQVELLHSFYTNQLDFKEEHVQFVKEVMKLEENQKGTLYGKTGTGIVNGHA
INGWFIGFVETETDTYFFATNIQQKIMHMEARLLKSLYPFCQAKEFID


>gb|EF540343.1|-|1464-3230|blaR1 [Alkalihalobacillus clausii]
ATGACGTTACCGCATATTTTACTTTCTCTTGTATTAATAACGGCAACGATTCTAGTGATCTTTTTTGTAAGAGCGGTTTTTTATAAACAA
TTATCAGCAAAATGGCGTTATCATTTATGGTTTTTACTCATTACTGTGTTGACGCTTCCGTTTATACCGATTCATCTATTGACGGGCTTG
TCTTTTTTTGACCAGGGGCGTCAACAGATTACCCCTTCAGCACAGAAGCGTTTCGGTTTTGCGGATCAAAATGAGCAATGGATGGTTGAT
TTTGGCACGTCTGTTAGTCGCTTTGACGATACATTCATTCATGCAGTGTTTGTTTCCATCTGGATTGGTGGAATGATTTTTTTCCTTTTA
TTGACTTTATACCATTATGCAAAGCTACAACGACTAGTAAAAGCGGCAAGTCGTATACAAAATCAAAAAGTCGAAAACGCGTTTAGCGAT
TGTATGGCAGAATTGCAAATAACGAATAAATTAACCAATTTAGAATCCCCTGCCATTCAAACGCCAATGACCTTTGGATGGTTAAAGACG
TACATCTTGTTGCCCAAAAATATCGAATTGTATCTATCTGATGATGAAATCAGACATGTGTTGTTGCATGAGTTGCACCATTATAAAAGC
AAACATATTAAAGTGAACTATATATTTGTCGTTTACCAAATTGTTTATTGGTTTCATCCTTTAGTATGGAAAGCCTTTAAAGAGATGCGT
CTTGATCGGGAATTAGCTTGTGATACGGAGGTCTTGCTTACATTGGGACAGCGGGAGTATAAAGCGTATGGCCAGACGATCATGCGTTTT
CTGGAAAGAAATTCTCGATTTTTATACTTAACGAACCCACTGCATAGTTCGAAAAAAGCTTTTAAAAATACGAAATCTTATAACATTGCT
TTCTTTTACTGGCGAGTCAAAAGCGGCGCCCAATTAAAAAAGCCATGGGTGGTTTTTGCTGGTCTCACCCGTTTTTGCATTGCTCAATTT
CCTTTTTTAACGGCAACCGCTGTTTCTACAGAGCGCTACCAATTTGATGAAAGCCAGGCGGTTGTTGAAGATTACAGCACTTATTTTGCA
GGAAATGAGGGTAGTTTTGTATTATATAGCTTAACCAGCGACCAGTTCGAAATCTATAATAAAGAAAAAAGTGTAAGAAGAGTCTCCCCC
AATTCTTCCTATAAAATTTACACCGCGCTCATGGCATTGGAACTAGGCGTGATTGGGCGAGATGATTCATGGTTAGAGTGGGATGGAGTC
GAATACGAGGATGAAGCCTGGAATAGCGGGCAAGATTTGAAATCGGCGATGAGCCAGTCAGTCACTTGGTACTTTCAAGAGTTAGACGAG
CGGATCAAACAAAGGAACATCCAATCTTTTGTAAACCAATTAGACTATGGGAATAAAGATCTTTCCGGTGGATTAAATCACTATTGGCTG
GAATCTTCCTTGAAAATATCACCGGTAGAACAAGTGGAGCTTCTCCATTCCTTCTATACAAACCAACTGGACTTTAAAGAAGAGCATGTG
CAATTCGTTAAAGAGGTTATGAAACTTGAAGAAAATCAAAAGGGAACGCTTTATGGAAAAACCGGGACTGGCATTGTGAACGGCCATGCA
ATAAATGGTTGGTTTATTGGATTTGTCGAAACTGAAACGGATACGTACTTTTTTGCGACAAACATTCAACAGAAGATCATGCATATGGAA
GCACGGCTGCTGAAATCACTTTATCCATTCTGTCAAGCAAAGGAATTTATTGATTAG