| Accession | ARO:3000238 |
| CARD Short Name | vanB_cluster |
| Definition | This inducible cluster confers resistance to vancomycin but organisms remain sensitive to teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Sensitivity to teicoplanin is due to lack of binding to the sensor kinase VanS. The vanB gene cluster can be located either on plasmids or on the chromosome. Gene orientation: vanRSYWHBX. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
| Sub-Term(s) | 8 ontology terms | Show + vanB part_of + vanH gene in vanB cluster part_of + vanR gene in vanB cluster part_of + vanW gene in vanB cluster part_of + vanS gene in vanB cluster part_of + vanX gene in vanB cluster part_of + vanY gene in vanB cluster part_of + vanV gene in vanB cluster part_of |
| Publications | Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) Quintiliani R, et al. 1996. Gene 172(1):1-8 Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. (PMID 8654967) |
Prevalence of glycopeptide resistance gene cluster VanB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster VanB
Model Description:
Regulatory: vanR gene in vanB clustervanS gene in vanB cluster
Core: vanBvanH gene in vanB clustervanX gene in vanB cluster
Accessory: vanVvanY gene in vanB clustervanW gene in vanB cluster