vanW gene in vanB cluster

Accession ARO:3002964
Synonym(s)vanW-B vanWB
CARD Short NamevanW_in_vanB_cl
DefinitionAlso known as vanWB, is a vanW variant found in the vanB gene cluster.
AMR Gene Familyglycopeptide resistance gene cluster, vanW
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesEnterococcus faecalisg+wgs+gi, Enterococcus faeciumwgs
Resistomes with Sequence VariantsBacillus cereuswgs, Bacillus thuringiensiswgs, Brevibacillus brevisg+wgs, Brevibacillus laterosporusg+wgs, Dysosmobacter welbionisg+wgs, Eikenella corrodensg+wgs, Enterocloster clostridioformiswgs, Enterococcus faecalisg+wgs+gi, Enterococcus faeciumg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg+wgs, Providencia rettgerig+wgs, Staphylococcus aureuswgs, Staphylococcus warneriwgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ vanW [AMR Gene Family]
+ part_of glycopeptide resistance gene cluster VanB
Publications

Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116)

Evers S and Courvalin P. 1996. J Bacteriol 178(5): 1302-1309. Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. (PMID 8631706)

Resistomes

Prevalence of vanW gene in vanB cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Bacillus cereus0%0%1%0%0%
Bacillus thuringiensis0%0%0.52%0%0%
Brevibacillus brevis85.71%0%70%0%0%
Brevibacillus laterosporus16.67%0%55.88%0%0%
Dysosmobacter welbionis100%0%100%0%0%
Eikenella corrodens66.67%0%78.95%0%0%
Enterocloster clostridioformis0%0%2.33%0%0%
Enterococcus faecalis2.27%0%2.95%16.67%0%
Enterococcus faecium6.05%0.45%6.89%13.73%0%
Proteus penneri0%0%12.5%0%0%
Providencia alcalifaciens100%0%96.55%0%0%
Providencia rettgeri29.41%0%36.31%0%0%
Staphylococcus aureus0%0%0.07%0%0%
Staphylococcus warneri0%0%9.84%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 50


>gb|AAB05625.1|+|vanW gene in vanB cluster [Enterococcus faecalis]
MNRKRLTQRFPFLLPMRQAQRKICFYAGMRFDGCCYAQTIGEKTLPYLLFETDCALYNHNTGFDMIYQENKVFNLKLAAKTLNGLLIKPG
ETFSFWRLVRHADKDTPYKDGLTVANGKLTTMSGGGMCQMSNLLFWVFLHTPLTIIQRSGHVVKEFPEPNSDEIKGVDATISEGWIDLKV
RNDTDCTYQIWVTLDDEKIIGQVFADKQPQALYKIANGSIQYVRESGGIYEYAKVERMQVALGTGEIIDCKLLYTNKCKICYPLPESVDI
QEANQ


>gb|U35369.1|+|3183-4010|vanW gene in vanB cluster [Enterococcus faecalis]
ATGAACAGAAAAAGATTGACACAGCGCTTCCCGTTCCTGCTTCCAATGAGACAAGCGCAGAGAAAAATATGCTTTTATGCGGGAATGAGA
TTTGACGGCTGTTGCTATGCACAGACGATAGGAGAAAAAACGCTTCCCTATTTGCTCTTTGAAACGGATTGTGCGTTATACAACCACAAT
ACCGGATTTGACATGATATACCAAGAAAACAAGGTGTTCAACTTAAAGCTGGCGGCAAAGACCTTAAACGGCCTATTGATAAAACCGGGG
GAAACCTTTTCTTTCTGGCGGCTGGTACGCCATGCGGACAAAGATACCCCCTATAAAGACGGCCTTACGGTGGCCAATGGTAAGCTCACC
ACCATGTCGGGCGGCGGTATGTGCCAGATGAGCAATTTACTATTTTGGGTGTTCCTGCATACGCCATTGACAATTATCCAGCGCAGCGGT
CACGTAGTAAAGGAGTTTCCAGAGCCAAACAGTGACGAGATCAAAGGGGTGGATGCAACCATCTCAGAGGGCTGGATTGATTTAAAAGTG
CGAAACGATACCGACTGCACCTACCAAATATGGGTGACCCTAGATGATGAGAAAATCATCGGTCAGGTGTTCGCCGACAAACAGCCTCAA
GCATTATACAAAATTGCAAACGGCAGTATTCAGTATGTCCGTGAAAGTGGCGGGATTTATGAATATGCCAAGGTTGAACGGATGCAAGTT
GCCTTAGGTACCGGGGAAATAATAGATTGCAAGCTGCTTTATACAAACAAATGCAAAATCTGCTATCCCCTCCCGGAAAGTGTGGATATT
CAGGAGGCGAACCAATGA

Curator Acknowledgements
Curator Description Most Recent Edit